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    npp-9 Nuclear Pore complex Protein [ Caenorhabditis elegans ]

    Gene ID: 175443, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npp-9
    Official Full Name
    Nuclear Pore complex Protein
    Primary source
    WormBase:WBGene00003795
    Locus tag
    CELE_F59A2.1
    See related
    AllianceGenome:WB:WBGene00003795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Predicted to contribute to GTPase activator activity. Involved in embryo development and nucleus organization. Part of nuclear pore. Human ortholog(s) of this gene implicated in brain disease and inflammatory myofibroblastic tumor. Orthologous to human RANBP2 (RAN binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npp-9 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (3400644..3404276, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Conserved regulator of innate immunity protein 3 Neighboring gene Pre-mRNA cleavage complex subunit Clp1 C-terminal domain-containing protein;Protein clpf-1 Neighboring gene ACT domain-containing protein Neighboring gene GRIP domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates. Franz C, et al. EMBO J, 2005 Oct 19. PMID 16193066, Free PMC Article
    2. Perinuclear P granules are the principal sites of mRNA export in adult C. elegans germ cells. Sheth U, et al. Development, 2010 Apr. PMID 20223759, Free PMC Article
    3. Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C. elegans embryos. Joseph-Strauss D, et al. Dev Biol, 2012 May 15. PMID 22426005, Free PMC Article
    4. Caenorhabditis elegans nucleoporins Nup93 and Nup205 determine the limit of nuclear pore complex size exclusion in vivo. Galy V, et al. Mol Biol Cell, 2003 Dec. PMID 12937276, Free PMC Article
    5. The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans. Weng C, et al. Genes Dev, 2019 Jan 1. PMID 30567997, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nuclear Pore complex Protein
    NP_001369848.1
    • Confirmed by transcript evidence
    NP_001370159.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3400644..3404276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001384053.2 → NP_001369848.1  Nuclear Pore complex Protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21021
      Conserved Domains (5) summary
      smart00160
      Location:255 → 384
      RanBD; Ran-binding domain
      smart00547
      Location:438 → 462
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:440 → 459
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam05109
      Location:147 → 233
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam15967
      Location:534 → 699
      Nucleoporin_FG2; Nucleoporin FG repeated region

    2. NM_001384054.1 → NP_001370159.1  Nuclear Pore complex Protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86G90
      Conserved Domains (5) summary
      smart00160
      Location:750 → 880
      RanBD; Ran-binding domain
      smart00547
      Location:462 → 486
      ZnF_RBZ; Zinc finger domain
      sd00029
      Location:464 → 483
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam05109
      Location:147 → 233
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam15967
      Location:547 → 723
      Nucleoporin_FG2; Nucleoporin FG repeated region
    Nucleotide Protein
    Heading Accession and Version

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