lin-32 Protein lin-32 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lin-32
Official Full Name: Protein lin-32
Primary source: WormBase:WBGene00003018
Locus tag: CELE_T14F9.5
See related: AllianceGenome:WB:WBGene00003018
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein heterodimerization activity; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of gliogenesis; nematode male tail tip morphogenesis; and neurogenesis. Located in nucleus. Is expressed in several structures, including QL; QL.a; QR; oxygen sensory neurons; and ray precursor cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 89. Orthologous to human ATOH1 (atonal bHLH transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lin-32 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 3

Sequence:: Chromosome: X; NC_003284.9 (2229055..2230122, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans.
Title: Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans.
LIN-32 may promote different target gene expression in neuroblast development.
Title: A proneural gene controls C. elegans neuroblast asymmetric division and migration.
our results illustrate a mechanism whereby the regulated function of a proneural-class gene in a single neural lineage can both specify a neural precursor and actively pattern the fates of its progeny
Title: The Wnt/beta-catenin asymmetry pathway patterns the atonal ortholog lin-32 to diversify cell fate in a Caenorhabditis elegans sensory lineage.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T14F9.5 (e-PCR)
- UniSTS:317070

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell differentiation involved in amphid sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gliogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein lin-32

NP_508410.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

2229055..2230122 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076009.4 → NP_508410.2 Protein lin-32 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508410.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10574

Conserved Domains (1) summary

pfam00010
Location:73 → 124

HLH; Helix-loop-helix DNA-binding domain