ajm-1 Apical junction molecule [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ajm-1
Official Full Name: Apical junction molecule
Primary source: WormBase:WBGene00000100
Locus tag: CELE_C25A11.4
See related: AllianceGenome:WB:WBGene00000100
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cytoskeletal protein binding activity. Involved in cell-cell junction organization and embryo development. Located in several cellular components, including adherens junction; apicolateral plasma membrane; and dendrite terminus. Is expressed in several structures, including gonad and pharynx. Orthologous to human AJM1 (apical junction component 1 homolog). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ajm-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 30

Sequence:: Chromosome: X; NC_003284.9 (9082946..9113619)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C. elegans Girdin also regulates localization of the apical junction component AJM-1, suggesting that in nematodes Girdin may position BBs via rootletin- and AJM-1-dependent anchoring to the cytoskeleton and plasma membrane, respectively. Together, our results describe a conserved role for Girdin in BB positioning and ciliogenesis
Title: A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.
These results represent the first in vivo analysis of requirements for the L27 domain of a Discs-large/SAP97 protein, identify a crucial LET-413/Scribble regulatory motif.
Title: Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C25A11.4 (e-PCR)
- UniSTS:317454

H08J11_21.c (e-PCR)
- UniSTS:323892

ha3118 (e-PCR)
- UniSTS:515655

C25A11.3 (e-PCR)
- UniSTS:312186

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction organization	IEA Inferred from Electronic Annotation more info
involved_in cell-cell junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in apical junction complex	IBA Inferred from Biological aspect of Ancestor more info
located_in apical junction complex	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in dendrite terminus	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Apical junction molecule

NP_001317734.1

Confirmed by transcript evidence

NP_001317736.1

Confirmed by transcript evidence

NP_001317888.1

Confirmed by transcript evidence

NP_001317889.1

Confirmed by transcript evidence

NP_001317890.1

Partially confirmed by transcript evidence

NP_001317891.1

Confirmed by transcript evidence

NP_001317897.1

Confirmed by transcript evidence

NP_001317898.1

Confirmed by transcript evidence

NP_001317899.1

Confirmed by transcript evidence

NP_001367381.1

Confirmed by transcript evidence

NP_001367382.1

Confirmed by transcript evidence

NP_001367383.1

Confirmed by transcript evidence

NP_001368606.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

9082946..9113619

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381048.1 → NP_001367381.1 Apical junction molecule [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

PTZ00121
Location:171 → 768

PTZ00121; MAEBL; Provisional

COG3064
Location:266 → 383

TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]

pfam01753
Location:1281 → 1324

zf-MYND; MYND finger
NM_001330906.2 → NP_001317734.1 Apical junction molecule [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q95ZY7
NM_001381046.2 → NP_001367383.1 Apical junction molecule [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

PTZ00121
Location:672 → 808

PTZ00121; MAEBL; Provisional

pfam01753
Location:1665 → 1708

zf-MYND; MYND finger
NM_001381045.1 → NP_001368606.1 Apical junction molecule [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

PTZ00121
Location:672 → 808

PTZ00121; MAEBL; Provisional

pfam01753
Location:1706 → 1749

zf-MYND; MYND finger
NM_001381047.3 → NP_001367382.1 Apical junction molecule [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2KYC5

Conserved Domains (1) summary

PTZ00121
Location:672 → 808

PTZ00121; MAEBL; Provisional
NM_001330908.3 → NP_001317889.1 Apical junction molecule [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1C3NSK1, A0A1C3NSK9, A0A1C3NSL1, A0A1C3NSL6, A0A1C3NSL9, A0A1C3NSM8, A0A1C3NSP2, A0A1C3NSQ2, G4RTG4, H2KYC4, H2KYC6

Conserved Domains (3) summary

pfam01753
Location:1445 → 1488

zf-MYND; MYND finger

pfam05672
Location:426 → 545

MAP7; MAP7 (E-MAP-115) family

cl26511
Location:335 → 932

Neuromodulin_N; Gap junction protein N-terminal region
NM_001330909.3 → NP_001317890.1 Apical junction molecule [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1C3NSL9
NM_001330910.3 → NP_001317891.1 Apical junction molecule [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1C3NSL9
NM_001330911.3 → NP_001317888.1 Apical junction molecule [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1C3NSL9
NM_001330912.3 → NP_001317897.1 Apical junction molecule [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1C3NSL9
NM_001330913.3 → NP_001317898.1 Apical junction molecule [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1C3NSL9
NM_001330914.3 → NP_001317899.1 Apical junction molecule [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1C3NSL9
NM_001330915.3 → NP_001317736.1 Apical junction molecule [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A1C3NSL9