csp-1 Caspase A subunit p16 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: csp-1
Official Full Name: Caspase A subunit p16
Primary source: WormBase:WBGene00000819
Locus tag: CELE_Y48E1B.13
See related: AllianceGenome:WB:WBGene00000819
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cysteine-type endopeptidase activity. Involved in several processes, including negative regulation of cellular response to manganese ion; positive regulation of apoptotic process; and protein processing. Located in germ cell nucleus. Is expressed in germ line. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis; breast cancer; carcinoma (multiple); gastrointestinal system cancer (multiple); and neurodegenerative disease (multiple). Orthologous to several human genes including CASP14 (caspase 14); CASP3 (caspase 3); and CASP6 (caspase 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See csp-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (13601204..13605057)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CSP-1 is a pro-apoptotic caspase that promotes programmed cell death in a subset of cells fated to die during C. elegans embryogenesis.
Title: Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y48E1B.13 (e-PCR)
- UniSTS:308183

STS2-210 (e-PCR)
- UniSTS:241886

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular response to manganese ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process involved in development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of apoptotic process involved in development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular response to gamma radiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoprocessing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Caspase A subunit p16

NP_001022452.1

Confirmed by transcript evidence

NP_001022453.1

Confirmed by transcript evidence

NP_001022454.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

13601204..13605057

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027281.1 → NP_001022452.1 Caspase A subunit p16 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022452.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EBM1, G5EBN4, G5EG94

Conserved Domains (2) summary

smart00115
Location:285 → 533

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

smart00583
Location:76 → 188

SPK; domain in SET and PHD domain containing proteins and protein kinases
NM_001027282.1 → NP_001022453.1 Caspase A subunit p16 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022453.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EBM1

Conserved Domains (1) summary

smart00115
Location:17 → 265

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
NM_001027283.1 → NP_001022454.1 Caspase A subunit p16 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022454.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EBM1

Conserved Domains (1) summary

cl00042
Location:17 → 146

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...