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    acr-21 AcetylCholine Receptor [ Caenorhabditis elegans ]

    Gene ID: 185004, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acr-21
    Official Full Name
    AcetylCholine Receptor
    Primary source
    WormBase:WBGene00000060
    Locus tag
    CELE_F27B3.2
    See related
    AllianceGenome:WB:WBGene00000060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in chemical synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Predicted to be located in postsynaptic membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in cholinergic neurons and ventral cord neurons. Human ortholog(s) of this gene implicated in lung small cell carcinoma. Orthologous to several human genes including CHRNA9 (cholinergic receptor nicotinic alpha 9 subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acr-21 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (6581885..6586580)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Zinc finger protein 263 Neighboring gene D-aspartate oxidase 3 Neighboring gene Differentially expressed in FDCP 8 homolog Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drug-dependent behaviors and nicotinic acetylcholine receptor expressions in Caenorhabditis elegans following chronic nicotine exposure. Polli JR, et al. Neurotoxicology, 2015 Mar. PMID 25530353, Free PMC Article
    2. A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels. Feng Z, et al. Cell, 2006 Nov 3. PMID 17081982, Free PMC Article
    3. Nicotine Motivated Behavior in C. elegans. Salim C, et al. Int J Mol Sci, 2024 Jan 29. PMID 38338915, Free PMC Article
    4. Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15. Sellings L, et al. Eur J Neurosci, 2013 Mar. PMID 23351035
    5. Activation of nicotinic receptors uncouples a developmental timer from the molting timer in C. elegans. Ruaud AF, et al. Development, 2006 Jun. PMID 16672334

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transmembrane transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    AcetylCholine Receptor
    NP_001355512.1
    • Product from WormBase gene class acr;
      Confirmed by transcript evidence
    NP_001355513.1
    • Product from WormBase gene class acr;
      Confirmed by transcript evidence
    NP_001355514.1
    • Product from WormBase gene class acr;
      Confirmed by transcript evidence
    NP_001355515.1
    • Product from WormBase gene class acr;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6581885..6586580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001368430.2 → NP_001355512.1  AcetylCholine Receptor [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6P985
      Conserved Domains (2) summary
      cd18997
      Location:56 → 237
      LGIC_ECD_nAChR; extracellular domain of nicotinic acetylcholine receptor
      cd19051
      Location:239 → 327
      LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC

    2. NM_001368431.3 → NP_001355513.1  AcetylCholine Receptor [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6NP92
      Conserved Domains (2) summary
      cd18997
      Location:56 → 237
      LGIC_ECD_nAChR; extracellular domain of nicotinic acetylcholine receptor
      cd19051
      Location:239 → 327
      LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC

    3. NM_001368432.3 → NP_001355514.1  AcetylCholine Receptor [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6MY71
      Conserved Domains (2) summary
      cd18997
      Location:25 → 206
      LGIC_ECD_nAChR; extracellular domain of nicotinic acetylcholine receptor
      cd19051
      Location:208 → 296
      LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC

    4. NM_001368433.3 → NP_001355515.1  AcetylCholine Receptor [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3P6N6F5
      Conserved Domains (2) summary
      cd18997
      Location:25 → 206
      LGIC_ECD_nAChR; extracellular domain of nicotinic acetylcholine receptor
      cd19051
      Location:208 → 296
      LGIC_TM_cation; transmembrane domain of Cys-loop neurotransmitter-gated ion channels, includes 5HT3, nAChR, and ZAC
    Nucleotide Protein
    Heading Accession and Version

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