U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    csq-1 Calsequestrin [ Caenorhabditis elegans ]

    Gene ID: 181563, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    csq-1
    Official Full Name
    Calsequestrin
    Primary source
    WormBase:WBGene00000822
    Locus tag
    CELE_F40E10.3
    See related
    AllianceGenome:WB:WBGene00000822
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calcium ion binding activity. Involved in calcium ion homeostasis. Located in several cellular components, including apical plasma membrane; nucleus; and sarcolemma. Is expressed in body wall musculature; isthmus; terminal bulb; and vulval muscle. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 2 and type 2 diabetes mellitus. Orthologous to human CASQ1 (calsequestrin 1) and CASQ2 (calsequestrin 2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See csq-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (14684877..14688322)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Slit homolog 1 protein Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. An optogenetic arrhythmia model to study catecholaminergic polymorphic ventricular tachycardia mutations. Fischer E, et al. Sci Rep, 2017 Dec 13. PMID 29235522, Free PMC Article
    2. Functional importance of polymerization and localization of calsequestrin in C. elegans. Cho JH, et al. J Cell Sci, 2007 May 1. PMID 17405817
    3. Arrhythmic Effects Evaluated on Caenorhabditis elegans: The Case of Polypyrrole Nanoparticles. Srinivasan SY, et al. ACS Nano, 2023 Sep 12. PMID 37624669, Free PMC Article
    4. Calsequestrin, a calcium sequestering protein localized at the sarcoplasmic reticulum, is not essential for body-wall muscle function in Caenorhabditis elegans. Cho JH, et al. J Cell Sci, 2000 Nov. PMID 11058082
    5. Evaluation and identification of reliable reference genes for toxicological study in Caenorhabditis elegans. Wu H, et al. Mol Biol Rep, 2014 May. PMID 24510408

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Polymerization of CSQ-1 is essential but not sufficient for correct cellular localization and function of CSQ-1.
      Title: Functional importance of polymerization and localization of calsequestrin in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sarcoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Calsequestrin
    NP_510438.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14684877..14688322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078037.8 → NP_510438.1  Calsequestrin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510438.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20203
      Conserved Domains (3) summary
      cd03074
      Location:256 → 385
      PDI_b'_Calsequestrin_C; Protein Disulfide Isomerase (PDIb') family, Calsequestrin subfamily, C-terminal TRX-fold domain; Calsequestrin is the major calcium storage protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It stores calcium ions in sufficient ...
      pfam01216
      Location:31 → 390
      Calsequestrin; Calsequestrin
      cl00388
      Location:34 → 151
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools