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    cdd-1 Cytidine deaminase [ Caenorhabditis elegans ]

    Gene ID: 183546, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdd-1
    Official Full Name
    Cytidine deaminase
    Primary source
    WormBase:WBGene00000391
    Locus tag
    CELE_C47D2.2
    See related
    AllianceGenome:WB:WBGene00000391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA binding activity and cytidine deaminase activity. Involved in RNA modification; deoxycytidine catabolic process; and uridine biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdd-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (8208748..8211149, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene RBR-type E3 ubiquitin transferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Neuropeptide-Like Protein Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical and molecular characterization of two cytidine deaminases in the nematode Caenorhabditis elegans. Thompson FJ, et al. Biochem J, 2002 Jul 1. PMID 12071843, Free PMC Article
    2. Tissue-specific modification of gld-2 mRNA in C. elegans: likely C-to-U editing. Wang L, et al. RNA, 2004 Sep. PMID 15317977, Free PMC Article
    3. Differentially expressed, abundant trans-spliced cDNAs from larval Brugia malayi. Gregory WF, et al. Mol Biochem Parasitol, 1997 Jul. PMID 9233676
    4. Nucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling in C. elegans. Chi C, et al. Genes Dev, 2016 Feb 1. PMID 26833730, Free PMC Article
    5. Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease. Jia F, et al. Cell Rep, 2020 Feb 11. PMID 32049015, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytidine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytidine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytidine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytidine deaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in RNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytidine deamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytidine deamination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in deoxycytidine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in uridine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cytidine deaminase
    NP_509384.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8208748..8211149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076983.5 → NP_509384.1  Cytidine deaminase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22922
      Conserved Domains (2) summary
      COG0295
      Location:11 → 140
      Cdd; Cytidine deaminase [Nucleotide transport and metabolism]
      cl00269
      Location:14 → 139
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
    Nucleotide Protein
    Heading Accession and Version

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