U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    unc-70 Spectrin beta chain [ Caenorhabditis elegans ]

    Gene ID: 179077, updated on 2-Nov-2024

    Summary

    Official Symbol
    unc-70
    Official Full Name
    Spectrin beta chain
    Primary source
    WormBase:WBGene00006803
    Locus tag
    CELE_K11C4.3
    See related
    AllianceGenome:WB:WBGene00006803
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Involved in several processes, including dendrite development; embryonic body morphogenesis; and muscle cell cellular homeostasis. Located in cell junction; contractile muscle fiber; and lateral plasma membrane. Is expressed in several structures, including hermaphrodite gonad; intestinal muscle; nervous system; vulval cell; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 14; hereditary spherocytosis; hereditary spherocytosis type 2; and spinocerebellar ataxia type 5. Orthologous to several human genes including SPTB (spectrin beta, erythrocytic). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See unc-70 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    15
    Sequence:
    Chromosome: V; NC_003283.11 (6881338..6891839)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Progestin and adipoQ receptor family member 3-like

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic body morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in I band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in M band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in organelle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of spectrin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Spectrin beta chain
    NP_001024052.1
    • Confirmed by transcript evidence
    NP_001024053.2
    • Confirmed by transcript evidence
    NP_001256073.1
    • Confirmed by transcript evidence
    NP_001294672.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6881338..6891839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028882.5NP_001024053.2  Spectrin beta chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024053.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95ZL8, Q9U9J8
      Conserved Domains (6) summary
      smart00150
      Location:20102088
      SPEC; Spectrin repeats
      cd00014
      Location:160264
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:11611370
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:21652266
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:21662266
      PH; PH domain
      pfam00307
      Location:41139
      CH; Calponin homology (CH) domain
    2. NM_001028881.5NP_001024052.1  Spectrin beta chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024052.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG85
      Conserved Domains (6) summary
      smart00150
      Location:20102088
      SPEC; Spectrin repeats
      cd00014
      Location:160264
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:11611370
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:21202221
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:21212221
      PH; PH domain
      pfam00307
      Location:41139
      CH; Calponin homology (CH) domain
    3. NM_001307743.4NP_001294672.1  Spectrin beta chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294672.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FN00
      Conserved Domains (6) summary
      smart00150
      Location:20102088
      SPEC; Spectrin repeats
      cd00014
      Location:160264
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:11611370
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:21482249
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:21492249
      PH; PH domain
      pfam00307
      Location:41139
      CH; Calponin homology (CH) domain
    4. NM_001269144.3NP_001256073.1  Spectrin beta chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256073.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0AHA7
      Conserved Domains (6) summary
      smart00150
      Location:20792157
      SPEC; Spectrin repeats
      cd00014
      Location:229333
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:12301439
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:21892290
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:21902290
      PH; PH domain
      pfam00307
      Location:110208
      CH; Calponin homology (CH) domain