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    rab-6.2 Ras-related protein rab-6.2 [ Caenorhabditis elegans ]

    Gene ID: 181759, updated on 9-Dec-2024

    Summary

    Official Symbol
    rab-6.2
    Official Full Name
    Ras-related protein rab-6.2
    Primary source
    WormBase:WBGene00004270
    Locus tag
    CELE_T25G12.4
    See related
    AllianceGenome:WB:WBGene00004270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTP binding activity. Involved in several processes, including early endosome to Golgi transport; positive regulation of feeding behavior; and protein stabilization. Located in Golgi trans cisterna. Is expressed in several structures, including alimentary muscle; hypodermis; nervous system; pharynx; and reproductive system. Orthologous to several human genes including RAB6A (RAB6A, member RAS oncogene family) and RAB6B (RAB6B, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See rab-6.2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (17222475..17224465)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Medium-chain specific acyl-CoA dehydrogenase, mitochondrial Neighboring gene ncRNA Neighboring gene VWFA domain-containing protein Neighboring gene Rhodanese domain-containing protein Neighboring gene Salivary glue protein Sgs-3-like

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in early endosome to Golgi transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of AMPA receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in Golgi cisterna IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi trans cisterna IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Ras-related protein rab-6.2
    NP_510790.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      17222475..17224465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078389.7NP_510790.1  Ras-related protein rab-6.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510790.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22782
      UniProtKB/TrEMBL
      I7FW36
      Conserved Domains (2) summary
      smart00175
      Location:11168
      RAB; Rab subfamily of small GTPases
      cd01861
      Location:11171
      Rab6; Rab GTPase family 6 (Rab6)