fmi-1 Cadherin EGF LAG seven-pass G-type receptor fmi-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fmi-1
Official Full Name: Cadherin EGF LAG seven-pass G-type receptor fmi-1
Primary source: WormBase:WBGene00001475
Locus tag: CELE_F15B9.7
See related: AllianceGenome:WB:WBGene00001475
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in anterior/posterior axon guidance and interneuron axon guidance. Located in axon. Is expressed in nervous system. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to several human genes including CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fmi-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 25

Sequence:: Chromosome: V; NC_003283.11 (13019061..13033401)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The adhesion GPCR and PCP component flamingo (FMI-1) alters body size and regulates the composition of the extracellular matrix.
Title: The adhesion GPCR and PCP component flamingo (FMI-1) alters body size and regulates the composition of the extracellular matrix.
fmi-1 appears to be working in a novel pathway, independently from the planar cell polarity pathway and in parallel to lin-17/frizzled and dsh-1/dishevelled, to determine the direction of neurite growth.
Title: C. elegans fmi-1/flamingo and Wnt pathway components interact genetically to control the anteroposterior neurite growth of the VD GABAergic neurons.
Caenorhabditis elegans Flamingo FMI-1 controls dendrite self-avoidance through F-actin assembly.
Title: Caenorhabditis elegans Flamingo FMI-1 controls dendrite self-avoidance through F-actin assembly.
FMI-1 is a cell-type dependent axon guidance factor with different domain requirements for its different functions in pioneers and followers.
Title: The Flamingo ortholog FMI-1 controls pioneer-dependent navigation of follower axons in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F15B9.7 (e-PCR)
- UniSTS:309771

STS5-206 (e-PCR)
- UniSTS:242368

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in anterior/posterior axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in anterior/posterior axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in interneuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cadherin EGF LAG seven-pass G-type receptor fmi-1

NP_001300071.1

Confirmed by transcript evidence

NP_001300072.1

Confirmed by transcript evidence

NP_506256.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

13019061..13033401

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073855.6 → NP_506256.3 Cadherin EGF LAG seven-pass G-type receptor fmi-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506256.3

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0K3ARX2, A0A0K3AUS4, G5EDK5

Conserved Domains (8) summary

smart00303
Location:2170 → 2218

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:274 → 371

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:1917 → 1974

HormR; Domain present in hormone receptors

cd00054
Location:1252 → 1287

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1865 → 1911

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:1333 → 1504

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd14964
Location:2258 → 2284

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:2237 → 2455

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001313142.3 → NP_001300071.1 Cadherin EGF LAG seven-pass G-type receptor fmi-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AUS4

Conserved Domains (7) summary

smart00303
Location:1811 → 1859

GPS; G-protein-coupled receptor proteolytic site domain

cd11304
Location:327 → 421

Cadherin_repeat; Cadherin tandem repeat domain

smart00008
Location:1558 → 1615

HormR; Domain present in hormone receptors

cd00054
Location:893 → 928

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1506 → 1552

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:974 → 1145

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl21561
Location:1878 → 2016

7tm_4; Olfactory receptor
NM_001313143.3 → NP_001300072.1 Cadherin EGF LAG seven-pass G-type receptor fmi-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ARX2

Conserved Domains (6) summary

smart00303
Location:1156 → 1204

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:903 → 960

HormR; Domain present in hormone receptors

cd00054
Location:238 → 273

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:851 → 897

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:319 → 490

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl21561
Location:1223 → 1361

7tm_4; Olfactory receptor