hsp-12.1 SHSP domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hsp-12.1
Official Full Name: SHSP domain-containing protein
Primary source: WormBase:WBGene00011906
Locus tag: CELE_T22A3.2
See related: AllianceGenome:WB:WBGene00011906
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in protein refolding and response to heat. Located in striated muscle dense body. Is expressed in body wall musculature. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease axonal type 2F; autosomal dominant distal hereditary motor neuronopathy 3; cataract (multiple); dilated cardiomyopathy 1II; and myofibrillar myopathy (multiple). Orthologous to several human genes including CRYAA (crystallin alpha A); CRYAB (crystallin alpha B); and HSPB6 (heat shock protein family B (small) member 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hsp-12.1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 2

Sequence:: Chromosome: I; NC_003279.8 (10581538..10582615, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T22A3.2 (e-PCR)
- UniSTS:317119

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in striated muscle dense body	HDA more info	PubMed

General protein information

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Preferred Names: SHSP domain-containing protein

NP_001076613.1

Confirmed by transcript evidence

NP_001076614.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10581538..10582615 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001083144.2 → NP_001076613.1 SHSP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001076613.1

Status: REVIEWED

UniProtKB/TrEMBL

O01263

Conserved Domains (1) summary

cd06526
Location:26 → 108

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
NM_001083145.4 → NP_001076614.1 SHSP domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001076614.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EE65

Conserved Domains (1) summary

cd06526
Location:26 → 111

metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...