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    • Showing Current items.

    aqp-4 Aquaporin [ Caenorhabditis elegans ]

    Gene ID: 179366, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aqp-4
    Official Full Name
    Aquaporin
    Primary source
    WormBase:WBGene00000172
    Locus tag
    CELE_F40F9.9
    See related
    AllianceGenome:WB:WBGene00000172
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables water channel activity. Involved in water transport. Located in apical plasma membrane. Is expressed in intestine. Orthologous to human AQP8 (aquaporin 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aqp-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (9737556..9739740)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Transcription factor CBF/NF-Y/archaeal histone domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein Neighboring gene RING-CH-type domain-containing protein Neighboring gene ncRNA Neighboring gene Signal transducer and activator of transcription b

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans. LaMacchia JC, et al. Am J Physiol Cell Physiol, 2015 Jul 15. PMID 26017147, Free PMC Article
    2. Functional characterization of a water channel of the nematode Caenorhabditis elegans. Kuwahara M, et al. Biochim Biophys Acta, 2000 Dec 15. PMID 11118622
    3. Isolation of C. elegans deletion mutants following ENU mutagenesis and thermostable restriction enzyme PCR screening. Huang CG, et al. Mol Biotechnol, 2006 Jan. PMID 16382185
    4. Functional analysis of the aquaporin gene family in Caenorhabditis elegans. Huang CG, et al. Am J Physiol Cell Physiol, 2007 May. PMID 17229810
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans.
      Title: Aquaporins-2 and -4 regulate glycogen metabolism and survival during hyposmotic-anoxic stress in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables water channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables water channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in water transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in water transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Aquaporin
    NP_505512.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9737556..9739740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073111.8 → NP_505512.3  Aquaporin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505512.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEK0
      Conserved Domains (1) summary
      cd00333
      Location:46 → 264
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    Nucleotide Protein
    Heading Accession and Version

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