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    bli-4 Endoprotease bli-4 [ Caenorhabditis elegans ]

    Gene ID: 172333, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bli-4
    Official Full Name
    Endoprotease bli-4
    Primary source
    WormBase:WBGene00000254
    Locus tag
    CELE_K04F10.4
    See related
    AllianceGenome:WB:WBGene00000254
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in several processes, including cellular response to salt; collagen and cuticulin-based cuticle development; and positive regulation of synaptic assembly at neuromuscular junction. Located in nucleus. Is expressed in head; hypodermis; intestine; reproductive system; and ventral cord neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bli-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    26
    Sequence:
    Chromosome: I; NC_003279.8 (6342224..6356680)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene MS Related Protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PAP-associated domain-containing protein Neighboring gene Vacuolar protein sorting-associated protein 28 homolog Neighboring gene Protein KATNIP homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and biochemical characterization of blisterase, a subtilisin-like convertase from the filarial parasite, Onchocerca volvulus. Poole CB, et al. J Biol Chem, 2003 Sep 19. PMID 12855702
    2. WABA success: a tool for sequence comparison between large genomes. Baillie DL, et al. Genome Res, 2000 Aug. PMID 10958624
    3. Mutational analysis of bli-4/kpc-4 reveals critical residues required for proprotein convertase function in C. elegans. Thacker C, et al. Gene, 2000 Jul 11. PMID 10903434
    4. Functional genomics in Caenorhabditis elegans: An approach involving comparisons of sequences from related nematodes. Thacker C, et al. Genome Res, 1999 Apr. PMID 10207157, Free PMC Article
    5. The bli-4 locus of Caenorhabditis elegans encodes structurally distinct kex2/subtilisin-like endoproteases essential for early development and adult morphology. Thacker C, et al. Genes Dev, 1995 Apr 15. PMID 7774813

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The proprotein convertase BLI-4 promotes collagen secretion prior to assembly of the Caenorhabditis elegans cuticle.
      Title: The proprotein convertase BLI-4 promotes collagen secretion prior to assembly of the Caenorhabditis elegans cuticle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to salt IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to salt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in collagen and cuticulin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptic assembly at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Endoprotease bli-4
    NP_001021540.1
    • Confirmed by transcript evidence
    NP_001021543.1
    • Confirmed by transcript evidence
    NP_001303778.1
    • Confirmed by transcript evidence
    NP_001303779.1
    • Confirmed by transcript evidence
    NP_001303781.1
    • Confirmed by transcript evidence
    NP_001360008.1
    • Confirmed by transcript evidence
    NP_001367785.1
    • Confirmed by transcript evidence
    NP_001367786.1
    • Partially confirmed by transcript evidence
    NP_001367787.1
    • Confirmed by transcript evidence
    NP_001368583.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6342224..6356680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001372959.2 → NP_001360008.1  Endoprotease bli-4 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd04059
      Location:160 → 448
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:536 → 623
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:43 → 116
      S8_pro-domain; Peptidase S8 pro-domain

    2. NM_001026372.7 → NP_001021543.1  Endoprotease bli-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021543.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0M7RDN9, A0A0M7RDU4, A0A0M7RE83, A0A0M7RFE9, G8JYA5, O44762, O44763, O44764, O44765, O44766, P51559
      Conserved Domains (6) summary
      cd04059
      Location:160 → 448
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:804 → 847
      FU; Furin-like repeats
      cd00064
      Location:675 → 728
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:536 → 623
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:43 → 116
      S8_pro-domain; Peptidase S8 pro-domain
      cl28643
      Location:716 → 856
      VSP; Giardia variant-specific surface protein

    3. NM_001316849.3 → NP_001303778.1  Endoprotease bli-4 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P51559
      Conserved Domains (4) summary
      cd04059
      Location:160 → 448
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:193 → 465
      Peptidase_S8; Subtilase family
      pfam01483
      Location:536 → 623
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:43 → 116
      S8_pro-domain; Peptidase S8 pro-domain

    4. NM_001316852.3 → NP_001303781.1  Endoprotease bli-4 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P51559
      Conserved Domains (4) summary
      cd04059
      Location:160 → 448
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:193 → 465
      Peptidase_S8; Subtilase family
      pfam01483
      Location:536 → 623
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:43 → 116
      S8_pro-domain; Peptidase S8 pro-domain

    5. NM_001316850.3 → NP_001303779.1  Endoprotease bli-4 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P51559
      Conserved Domains (4) summary
      cd04059
      Location:160 → 448
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:193 → 465
      Peptidase_S8; Subtilase family
      pfam01483
      Location:536 → 623
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:43 → 116
      S8_pro-domain; Peptidase S8 pro-domain

    6. NM_001026369.7 → NP_001021540.1  Endoprotease bli-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021540.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P51559
      Conserved Domains (4) summary
      cd04059
      Location:160 → 448
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:193 → 465
      Peptidase_S8; Subtilase family
      pfam01483
      Location:536 → 623
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:43 → 116
      S8_pro-domain; Peptidase S8 pro-domain

    7. NM_001380517.2 → NP_001367786.1  Endoprotease bli-4 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (5) summary
      cd04059
      Location:160 → 448
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:724 → 773
      FU; Furin-like repeats
      cd00064
      Location:675 → 728
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:536 → 623
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:43 → 116
      S8_pro-domain; Peptidase S8 pro-domain

    8. NM_001380518.3 → NP_001367785.1  Endoprotease bli-4 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd04059
      Location:160 → 448
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:536 → 623
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:43 → 116
      S8_pro-domain; Peptidase S8 pro-domain

    9. NM_001380521.1 → NP_001368583.1  Endoprotease bli-4 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd04059
      Location:160 → 448
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:536 → 623
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:43 → 116
      S8_pro-domain; Peptidase S8 pro-domain

    10. NM_001380523.1 → NP_001367787.1  Endoprotease bli-4 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd04059
      Location:160 → 448
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:536 → 623
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:43 → 116
      S8_pro-domain; Peptidase S8 pro-domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51559.3

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