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    pgp-11 P-GlycoProtein related [ Caenorhabditis elegans ]

    Gene ID: 183971, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pgp-11
    Official Full Name
    P-GlycoProtein related
    Primary source
    WormBase:WBGene00004005
    Locus tag
    CELE_DH11.3
    See related
    AllianceGenome:WB:WBGene00004005
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be active in membrane. Is expressed in excretory cell; intestine; and rectal gland cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pgp-11 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    17
    Sequence:
    Chromosome: II; NC_003280.10 (7995580..8004257, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene C2 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative glutaminase 2;glutaminase Neighboring gene F-box domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transgenically expressed Parascaris P-glycoprotein-11 can modulate ivermectin susceptibility in Caenorhabditis elegans. Janssen IJ, et al. Int J Parasitol Drugs Drug Resist, 2015 Aug. PMID 25905032, Free PMC Article
    2. Distinct regulatory elements mediate similar expression patterns in the excretory cell of Caenorhabditis elegans. Zhao Z, et al. J Biol Chem, 2005 Nov 18. PMID 16159881
    3. Resistance to the macrocyclic lactone moxidectin is mediated in part by membrane transporter P-glycoproteins: Implications for control of drug resistant parasitic nematodes. Bygarski EE, et al. Int J Parasitol Drugs Drug Resist, 2014 Dec. PMID 25516824, Free PMC Article
    4. The ABC transporter gene family of Caenorhabditis elegans has implications for the evolutionary dynamics of multidrug resistance in eukaryotes. Sheps JA, et al. Genome Biol, 2004. PMID 15003118, Free PMC Article
    5. Comparative genomics and adaptive selection of the ATP-binding-cassette gene family in caenorhabditis species. Zhao Z, et al. Genetics, 2007 Mar. PMID 17194779, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    P-GlycoProtein related
    NP_001364583.1
    • Product from WormBase gene class pgp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7995580..8004257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377827.2 → NP_001364583.1  P-GlycoProtein related [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19015
      Conserved Domains (2) summary
      COG1132
      Location:46 → 607
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      PTZ00265
      Location:38 → 1235
      PTZ00265; multidrug resistance protein (mdr1); Provisional
    Nucleotide Protein
    Heading Accession and Version

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