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    Y51A2D.1 Pept_C1 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180204, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y51A2D.1
    Official Full Name
    Pept_C1 domain-containing protein
    Primary source
    WormBase:WBGene00013072
    Locus tag
    CELE_Y51A2D.1
    See related
    AllianceGenome:WB:WBGene00013072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Orthologous to human CTSO (cathepsin O). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y51A2D.1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (18508864..18512643)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene BK channel;Calcium-activated potassium channel slo-1 Neighboring gene ncRNA Neighboring gene Proton myo-inositol cotransporter hmit-1.1 Neighboring gene ncRNA Neighboring gene Proton myo-inositol cotransporter hmit-1.2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Pept_C1 domain-containing protein
    NP_001256811.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      18508864..18512643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269882.2 → NP_001256811.1  Pept_C1 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256811.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62484
      Conserved Domains (2) summary
      smart00848
      Location:44 → 103
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      cd02248
      Location:144 → 303
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

    RNA

    1. NR_070167.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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