hsp-70 Heat shock protein 70 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hsp-70
Official Full Name: Heat shock protein 70
Primary source: WormBase:WBGene00002026
Locus tag: CELE_C12C8.1
See related: AllianceGenome:WB:WBGene00002026
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Involved in determination of adult lifespan and response to heat. Part of chaperonin-containing T-complex. Is expressed in anal depressor muscle; mu_int_L; and mu_int_R. Orthologous to human HSPA6 (heat shock protein family A (Hsp70) member 6) and HSPA7 (heat shock protein family A (Hsp70) member 7 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hsp-70 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (9320325..9322519, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The HSP110/HSP70 disaggregation system generates spreading-competent toxic alpha-synuclein species.
Title: The HSP110/HSP70 disaggregation system generates spreading-competent toxic α-synuclein species.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C12C8.1 (e-PCR)
- UniSTS:306009

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	HEP more info	PubMed
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chaperonin-containing T-complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Heat shock protein 70

NP_492485.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9320325..9322519 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060084.6 → NP_492485.1 Heat shock protein 70 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492485.1

Status: REVIEWED

UniProtKB/TrEMBL

O45246

Conserved Domains (2) summary

cd10233
Location:6 → 382

HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins

PTZ00009
Location:1 → 643

PTZ00009; heat shock 70 kDa protein; Provisional