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    nep-21 Neprilysin-2;Neprilysin-21 [ Caenorhabditis elegans ]

    Gene ID: 179925, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nep-21
    Official Full Name
    Neprilysin-2;Neprilysin-21
    Primary source
    WormBase:WBGene00011794
    Locus tag
    CELE_T16A9.4
    See related
    AllianceGenome:WB:WBGene00011794
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in accessory cell; anterior ganglion; lumbar ganglion; motor neurons; and ventral nerve cord. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nep-21 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    16
    Sequence:
    Chromosome: V; NC_003283.11 (14215339..14226473, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Seven TM Receptor Neighboring gene Membrane transporter protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Gln Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transgenic reporter analysis of ChIP-Seq-defined enhancers identifies novel target genes for the terminal selector UNC-3/Collier/Ebf. Li Y, et al. MicroPubl Biol, 2021. PMID 34549172, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-2;Neprilysin-21
    NP_001263884.1
    • Confirmed by transcript evidence
    NP_001343820.1
    • Confirmed by transcript evidence
    NP_001360525.1
    • Confirmed by transcript evidence
    NP_506520.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14215339..14226473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276955.4 → NP_001263884.1  Neprilysin-21 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263884.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      J7S146
      Conserved Domains (2) summary
      cd08662
      Location:106 → 775
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:95 → 777
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    2. NM_001356755.4 → NP_001343820.1  Neprilysin-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C3G3
      Conserved Domains (1) summary
      cd08662
      Location:193 → 854
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    3. NM_001373156.2 → NP_001360525.1  Neprilysin-21 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WVJ1
      Conserved Domains (1) summary
      cd08662
      Location:193 → 862
      M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

    4. NM_074119.8 → NP_506520.1  Neprilysin-21 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506520.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22523
      Conserved Domains (2) summary
      cd08662
      Location:106 → 767
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:95 → 769
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22523.2

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