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    spc-1 Spectrin alpha chain [ Caenorhabditis elegans ]

    Gene ID: 180603, updated on 14-Nov-2024

    Summary

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    Official Symbol
    spc-1
    Official Full Name
    Spectrin alpha chain
    Primary source
    WormBase:WBGene00004951
    Locus tag
    CELE_K10B3.10
    See related
    AllianceGenome:WB:WBGene00004951
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Involved in several processes, including embryonic body morphogenesis; nematode larval development; and regulation of growth. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in several cellular components, including cell junction; cortical actin cytoskeleton; and plasma membrane. Is expressed in several structures, including germ line; gonad; intestine; pharynx; and vulval cell. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 11; developmental and epileptic encephalopathy 5; hereditary spherocytosis; and hereditary spherocytosis type 3. Orthologous to several human genes including SPTAN1 (spectrin alpha, non-erythrocytic 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See spc-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (3117439..3127079, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase 2 Neighboring gene ATPase inhibitor mai-1, mitochondrial Neighboring gene Small EDRK-rich factor-like N-terminal domain-containing protein Neighboring gene Activin_recp domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The spectrin-based membrane skeleton is asymmetric and remodels during neural development in C. elegans. Jia R, et al. J Cell Sci, 2020 Aug 5. PMID 32620698
    2. SMA-1 spectrin has essential roles in epithelial cell sheet morphogenesis in C. elegans. Praitis V, et al. Dev Biol, 2005 Jul 1. PMID 15890334
    3. Apical-basal polarity of the spectrin cytoskeleton in the C. elegans vulva. Barker TJ, et al. MicroPubl Biol, 2023. PMID 37396793, Free PMC Article
    4. Spectrin regulates cell contractility through production and maintenance of actin bundles in the Caenorhabditis elegans spermatheca. Wirshing ACE, et al. Mol Biol Cell, 2018 Oct 1. PMID 30091661, Free PMC Article
    5. Spectrin: the ghost in the machine. Thomas GH. Bioessays, 2001 Feb. PMID 11169588

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A kinesin-1 adaptor complex controls bimodal slow axonal transport of spectrin in Caenorhabditis elegans.
      Title: A kinesin-1 adaptor complex controls bimodal slow axonal transport of spectrin in Caenorhabditis elegans.
    2. the spectrin cytoskeleton composed of SPC-1/alpha-spectrin, UNC-70/beta-spectrin, and SMA-1/beta heavy-spectrin as required for contractility and actin organization in the myoepithelial cells of the C. elegans spermathecal, were identified.
      Title: Spectrin regulates cell contractility through production and maintenance of actin bundles in the Caenorhabditis elegans spermatheca.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Spectrin alpha chain
    NP_001256999.1
    • Confirmed by transcript evidence
    NP_001257000.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3117439..3127079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270070.3 → NP_001256999.1  Spectrin alpha chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256999.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4S034
      Conserved Domains (6) summary
      smart00150
      Location:1407 → 1504
      SPEC; Spectrin repeats
      cd11808
      Location:987 → 1039
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      COG5126
      Location:2264 → 2421
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:2281 → 2349
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:62 → 272
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam08726
      Location:2356 → 2426
      EFhand_Ca_insen; Ca2+ insensitive EF hand

    2. NM_001270071.5 → NP_001257000.1  Spectrin alpha chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257000.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21408
      Conserved Domains (7) summary
      smart00150
      Location:1412 → 1509
      SPEC; Spectrin repeats
      cd11808
      Location:987 → 1039
      SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
      COG5126
      Location:2269 → 2426
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:2286 → 2354
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd00176
      Location:62 → 272
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:907 → 973
      Spectrin; Spectrin repeat
      pfam08726
      Location:2361 → 2431
      EFhand_Ca_insen; Ca2+ insensitive EF hand
    Nucleotide Protein
    Heading Accession and Version

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