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    sli-1 E3 ubiquitin-protein ligase CBL [ Caenorhabditis elegans ]

    Gene ID: 180419, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sli-1
    Official Full Name
    E3 ubiquitin-protein ligase CBL
    Primary source
    WormBase:WBGene00004829
    Locus tag
    CELE_M02A10.3
    See related
    AllianceGenome:WB:WBGene00004829
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable receptor tyrosine kinase binding activity and ubiquitin protein ligase activity. Involved in negative regulation of vulval development. Predicted to be active in membrane raft and plasma membrane. Is expressed in several structures, including anal depressor muscle; body wall musculature; distal tip cell; hypodermis; and intestine. Human ortholog(s) of this gene implicated in carcinoma (multiple); congestive heart failure; hematologic cancer (multiple); and type 1 diabetes mellitus. Orthologous to human CBL (Cbl proto-oncogene); CBLB (Cbl proto-oncogene B); and CBLC (Cbl proto-oncogene C). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See sli-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (720237..725968, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene NCAM (neural cell adhesion molecule) homolog Neighboring gene ncRNA Neighboring gene Inward rectifier potassium channel irk-1 Neighboring gene Uncharacterized protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene. Thien CB, et al. Oncogene, 1997 May 8. PMID 9174060
    2. C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype. Kanteti R, et al. Cancer Biol Ther, 2016. PMID 26574927, Free PMC Article
    3. SLI-1 Cbl inhibits the engulfment of apoptotic cells in C. elegans through a ligase-independent function. Anderson C, et al. PLoS Genet, 2012. PMID 23271977, Free PMC Article
    4. Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH. Courbard JR, et al. J Biol Chem, 2002 Nov 22. PMID 12226085
    5. Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl. Yoon CH, et al. Science, 1995 Aug 25. PMID 7652556

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We propose that SLI-1 opposes the engulfment of apoptotic cells via a previously unidentified pathway.
      Title: SLI-1 Cbl inhibits the engulfment of apoptotic cells in C. elegans through a ligase-independent function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase CBL
    NP_001024797.1
    • Confirmed by transcript evidence
    NP_001024798.1
    • Confirmed by transcript evidence
    NP_508145.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      720237..725968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029627.4 → NP_001024798.1  E3 ubiquitin-protein ligase CBL [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024798.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6ABG8
      Conserved Domains (4) summary
      cd09920
      Location:248 → 344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373 → 417
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam02262
      Location:50 → 166
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:170 → 254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    2. NM_001029626.4 → NP_001024797.1  E3 ubiquitin-protein ligase CBL [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024797.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95ZR5
      Conserved Domains (4) summary
      cd09920
      Location:248 → 344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373 → 417
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam02262
      Location:50 → 166
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:170 → 254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    3. NM_075744.9 → NP_508145.2  E3 ubiquitin-protein ligase CBL [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508145.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19019
      Conserved Domains (4) summary
      cd09920
      Location:265 → 361
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:390 → 434
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam02262
      Location:67 → 183
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:187 → 271
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    Nucleotide Protein
    Heading Accession and Version

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