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    dhs-21 L-xylulose reductase [ Caenorhabditis elegans ]

    Gene ID: 179741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhs-21
    Official Full Name
    L-xylulose reductase
    Primary source
    WormBase:WBGene00000984
    Locus tag
    CELE_R11D1.11
    See related
    AllianceGenome:WB:WBGene00000984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables L-xylulose reductase (NADPH) activity and carbonyl reductase (NADPH) activity. Involved in xylulose catabolic process. Located in plasma membrane. Is expressed in hermaphrodite gonad; hypodermis; and intestine. Human ortholog(s) of this gene implicated in pentosuria. Orthologous to human DCXR (dicarbonyl and L-xylulose reductase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhs-21 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (12731767..12733645, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF148 domain-containing protein Neighboring gene Large ribosomal subunit protein eL28 Neighboring gene Large ribosomal subunit protein mL49 Neighboring gene FYVE-type domain-containing protein Neighboring gene XK-related protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Human DCXR - another 'moonlighting protein' involved in sugar metabolism, carbonyl detoxification, cell adhesion and male fertility? Ebert B, et al. Biol Rev Camb Philos Soc, 2015 Feb. PMID 24720935
    2. DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans. Son le T, et al. FEBS Lett, 2011 May 6. PMID 21477590
    3. Bioinformatic and biochemical characterization of DCXR and DHRS2/4 from Caenorhabditis elegans. Kisiela M, et al. Chem Biol Interact, 2011 May 30. PMID 21300042
    4. Dicarbonyl/L-xylulose reductase (DCXR) producing xylitol regulates egg retention through osmolality control in Caenorhabditis elegans. Kim YN, et al. Anim Cells Syst (Seoul), 2022. PMID 36275448, Free PMC Article
    5. MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans. Sendoel A, et al. Cell Death Differ, 2019 Oct. PMID 30728462, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that DHS-21 is a bona fide DCXR of C. elegans, essential for normal life span and reproduction.
      Title: DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-xylulose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-xylulose reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-xylulose reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-xylulose reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carbonyl reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonyl reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables catalytic activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-xylose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xylulose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xylulose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xylulose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    L-xylulose reductase
    NP_506182.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12731767..12733645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073781.8 → NP_506182.2  L-xylulose reductase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506182.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21929, Q27GP8
      Conserved Domains (2) summary
      PRK07060
      Location:1 → 249
      PRK07060; short chain dehydrogenase; Provisional
      cd05351
      Location:3 → 251
      XR_like_SDR_c; xylulose reductase-like, classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21929.2

    Gene LinkOut

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