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    sbp-1 Processed sterol regulatory element binding protein sbp-1 [ Caenorhabditis elegans ]

    Gene ID: 176574, updated on 2-Nov-2024

    Summary

    Official Symbol
    sbp-1
    Official Full Name
    Processed sterol regulatory element binding protein sbp-1
    Primary source
    WormBase:WBGene00004735
    Locus tag
    CELE_Y47D3B.7
    See related
    AllianceGenome:WB:WBGene00004735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription factor activity. Involved in several processes, including cellular response to zinc ion; fatty acid metabolic process; and positive regulation of macromolecule biosynthetic process. Located in nucleus. Is expressed in several structures, including head; intestine; and terminal bulb. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); prostate cancer; sarcoma; and vascular dementia. Orthologous to several human genes including SREBF2 (sterol regulatory element binding transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See sbp-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (11428367..11442566, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Potassium channel domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EB domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative E3 ubiquitin-protein ligase plr-1

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Processed sterol regulatory element binding protein sbp-1
    NP_499472.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11428367..11442566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067071.8NP_499472.1  Processed sterol regulatory element binding protein sbp-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499472.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XX00
      Conserved Domains (2) summary
      pfam03154
      Location:30272
      Atrophin-1; Atrophin-1 family
      cl00081
      Location:351423
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily