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    gap-2 Ras GTPase-activating protein gap-2 [ Caenorhabditis elegans ]

    Gene ID: 181172, updated on 2-Nov-2024

    Summary

    Official Symbol
    gap-2
    Official Full Name
    Ras GTPase-activating protein gap-2
    Primary source
    WormBase:WBGene00001516
    Locus tag
    CELE_ZK899.8
    See related
    AllianceGenome:WB:WBGene00001516
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Involved in learning or memory and negative regulation of Ras protein signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including head muscle; non-striated muscle; seam cell; tail; and vulva. Human ortholog(s) of this gene implicated in artery disease (multiple); autosomal dominant intellectual developmental disorder 5; lung cancer; prostate cancer; and stomach cancer. Orthologous to several human genes including DAB2IP (DAB2 interacting protein); RASAL2 (RAS protein activator like 2); and SYNGAP1 (synaptic Ras GTPase activating protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See gap-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    27
    Sequence:
    Chromosome: X; NC_003284.9 (9472470..9516454)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PRESAN domain-containing protein Neighboring gene FLYWCH-type domain-containing protein Neighboring gene Uncharacterized protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in associative learning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in long-term memory IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Ras protein signal transduction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in short-term memory IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in short-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    Ras GTPase-activating protein gap-2
    NP_001123198.1
    • Partially confirmed by transcript evidence
    NP_001294843.1
    • Confirmed by transcript evidence
    NP_001294845.1
    • Confirmed by transcript evidence
    NP_001379449.1
    • Confirmed by transcript evidence
    NP_509594.3
    • Confirmed by transcript evidence
    NP_509595.1
    • Confirmed by transcript evidence
    NP_509596.1
    • Confirmed by transcript evidence
    NP_509597.1
    • Confirmed by transcript evidence
    NP_509598.1
    • Confirmed by transcript evidence
    NP_509599.1
    • Confirmed by transcript evidence
    NP_741873.1
    • Confirmed by transcript evidence
    NP_741874.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9472470..9516454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077193.7NP_509594.3  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509594.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZJ45, K8ERX6, K8ERY0, K8ESF6, K8ESL7, K8F7Z7, K8FE04, M1ZJ21, M1ZMJ4, O44239, O44240, O44241, O44242, O44243, O44244, O44245, Q3S1K5, Q8MLZ5, Q9TVD9, Q9TVE0, Q9TVE1, Q9TVE2, Q9TVE3, Q9TVE4, Q9U991, Q9UAH9, Q9UAI0
      Conserved Domains (4) summary
      cd04013
      Location:384534
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:525853
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:512857
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:242442
      PH-like; Pleckstrin homology-like domain
    2. NM_001307916.4NP_001294845.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294845.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:384534
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:525853
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:512857
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:242442
      PH-like; Pleckstrin homology-like domain
    3. NM_077194.8NP_509595.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509595.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:347497
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:488816
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:475820
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:213405
      PH-like; Pleckstrin homology-like domain
    4. NM_077195.8NP_509596.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509596.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:436586
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:577905
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:564909
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:302494
      PH-like; Pleckstrin homology-like domain
    5. NM_077196.6NP_509597.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509597.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:314464
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:455783
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:442787
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:180372
      PH-like; Pleckstrin homology-like domain
    6. NM_077197.6NP_509598.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509598.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:225375
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:366694
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:353698
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:83283
      PH-like; Pleckstrin homology-like domain
    7. NM_171753.7NP_741873.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741873.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:265415
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:406734
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:393738
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:131323
      PH-like; Pleckstrin homology-like domain
    8. NM_077198.7NP_509599.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509599.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:133283
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:274602
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:261606
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:27191
      PH-like; Pleckstrin homology-like domain
    9. NM_001307914.4NP_001294843.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294843.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (4) summary
      cd04013
      Location:125275
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:266594
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:253598
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:55183
      PH-like; Pleckstrin homology-like domain
    10. NM_001392821.1NP_001379449.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd04013
      Location:3153
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:144472
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    11. NM_001129726.4NP_001123198.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001123198.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (3) summary
      cd05136
      Location:108436
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:95440
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl14603
      Location:73117
      C2; C2 domain
    12. NM_171754.7NP_741874.1  Ras GTPase-activating protein gap-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741874.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MLZ5
      Conserved Domains (3) summary
      cd05136
      Location:105433
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:92437
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl14603
      Location:70114
      C2; C2 domain