odc-1 Ornithine decarboxylase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: odc-1
Official Full Name: Ornithine decarboxylase
Primary source: WormBase:WBGene00003844
Locus tag: CELE_K11C4.4
See related: AllianceGenome:WB:WBGene00003844
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ornithine decarboxylase activity. Involved in putrescine biosynthetic process from ornithine. Predicted to be active in cytoplasm. Is expressed in intestine and male gonad. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and liver cirrhosis. Orthologous to human AZIN1 (antizyme inhibitor 1); AZIN2 (antizyme inhibitor 2); and ODC1 (ornithine decarboxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See odc-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (6898540..6900223, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K11C4.4 (e-PCR)
- UniSTS:311551

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables ornithine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables ornithine decarboxylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in putrescine biosynthetic process from ornithine	IBA Inferred from Biological aspect of Ancestor more info
involved_in putrescine biosynthetic process from ornithine	IDA Inferred from Direct Assay more info	PubMed
involved_in putrescine biosynthetic process from ornithine	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ornithine decarboxylase

NP_504752.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6898540..6900223 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072351.7 → NP_504752.1 Ornithine decarboxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504752.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41931, Q94278

Conserved Domains (2) summary

cd00622
Location:39 → 407

PLPDE_III_ODC; Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase

COG0019
Location:17 → 402

LysA; Diaminopimelate decarboxylase [Amino acid transport and metabolism]