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    mig-32 Polycomb group RING finger protein 3 homolog mig-32 [ Caenorhabditis elegans ]

    Gene ID: 178150, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mig-32
    Official Full Name
    Polycomb group RING finger protein 3 homolog mig-32
    Primary source
    WormBase:WBGene00008684
    Locus tag
    CELE_F11A10.3
    See related
    AllianceGenome:WB:WBGene00008684
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables histone ubiquitin ligase activity. Involved in several processes, including negative regulation of vulval development; nematode male tail tip morphogenesis; and regulation of axon extension involved in axon guidance. Located in nucleolus. Is expressed in several structures, including germ line and ventral ganglion. Orthologous to human PCGF3 (polycomb group ring finger 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mig-32 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (12089286..12092213, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene ncRNA Neighboring gene Transmembrane protein 115 Neighboring gene Cleavage and polyadenylation specificity factor subunit 4 Neighboring gene Protein ST7 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trithorax, Hox, and TALE-class homeodomain proteins ensure cell survival through repression of the BH3-only gene egl-1. Potts MB, et al. Dev Biol, 2009 May 15. PMID 19254707
    2. MIG-32 and SPAT-3A are PRC1 homologs that control neuronal migration in Caenorhabditis elegans. Karakuzu O, et al. Development, 2009 Mar. PMID 19211678, Free PMC Article
    3. PRC1 chromatin factors strengthen the consistency of neuronal cell fate specification and maintenance in C. elegans. Bordet G, et al. PLoS Genet, 2022 May. PMID 35604893, Free PMC Article
    4. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. McCracken S, et al. J Biol Chem, 2003 Nov 7. PMID 12944400
    5. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables histone ubiquitin ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of axon extension involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Polycomb group RING finger protein 3 homolog mig-32
    NP_001255620.1
    • Confirmed by transcript evidence
    NP_001255621.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12089286..12092213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268691.2 → NP_001255620.1  Polycomb group RING finger protein 3 homolog mig-32 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255620.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3YT24, Q19336
      Conserved Domains (2) summary
      cd16735
      Location:326 → 373
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd16102
      Location:459 → 545
      RAWUL_PCGF_like; RRING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in PCGF1-6, RING1 and -2, DRIP and similar proteins; structurally similar to a beta-grasp ubiquitin-like fold

    2. NM_001268692.3 → NP_001255621.1  Polycomb group RING finger protein 3 homolog mig-32 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255621.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT24
      Conserved Domains (1) summary
      cl28922
      Location:1 → 36
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein
    Heading Accession and Version

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