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    ldh-1 L-lactate dehydrogenase [ Caenorhabditis elegans ]

    Gene ID: 174798, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ldh-1
    Official Full Name
    L-lactate dehydrogenase
    Primary source
    WormBase:WBGene00002262
    Locus tag
    CELE_F13D12.2
    See related
    AllianceGenome:WB:WBGene00002262
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables L-lactate dehydrogenase activity. Predicted to be involved in lactate metabolic process and pyruvate metabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in body wall musculature; hypodermis; nervous system; reproductive system; and tail. Orthologous to several human genes including LDHA (lactate dehydrogenase A); LDHAL6A (lactate dehydrogenase A like 6A); and LDHB (lactate dehydrogenase B). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ldh-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (11724204..11726533)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene MARVEL domain-containing protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Transmembrane protein Neighboring gene putative methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial Neighboring gene Col_cuticle_N domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nucleotide and deduced amino-acid sequences of a cDNA encoding lactate dehydrogenase from Caenorhabditis elegans: the evolutionary relationships of lactate dehydrogenases from mammals, birds, amphibian, fish, nematode, plants, bacteria, mycoplasma, and plasmodium. Tsoi SC, et al. Biochem Biophys Res Commun, 1994 Nov 30. PMID 7999079
    2. A Combined Cell-Worm Approach to Search for Compounds Counteracting the Toxicity of Tau Oligomers In Vivo. Natale C, et al. Int J Mol Sci, 2022 Sep 24. PMID 36232578, Free PMC Article
    3. The lactate dehydrogenase gene from nematode Caenorhabditis elegans contains only two of six introns conserved in the protein-encoding sequence of LDH genes from bird and mammals. Mannen H, et al. Biochem Mol Biol Int, 1995 Dec. PMID 8747535
    4. Functional assessment of hydrophilic domains of late embryogenesis abundant proteins from distant organisms. Liu Y, et al. Microb Biotechnol, 2019 Jul. PMID 31012266, Free PMC Article
    5. Ethanolic extract of Streblus asper leaves protects against glutamate-induced toxicity in HT22 hippocampal neuronal cells and extends lifespan of Caenorhabditis elegans. Prasansuklab A, et al. BMC Complement Altern Med, 2017 Dec 28. PMID 29282044, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-lactate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-lactate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    L-lactate dehydrogenase
    NP_001343759.1
    • Confirmed by transcript evidence
    NP_496503.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11724204..11726533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356894.2 → NP_001343759.1  L-lactate dehydrogenase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C320
      Conserved Domains (1) summary
      cd05293
      Location:36 → 333
      LDH_1; A subgroup of L-lactate dehydrogenases

    2. NM_064102.6 → NP_496503.1  L-lactate dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496503.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27888
      Conserved Domains (2) summary
      cd05293
      Location:33 → 330
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:33 → 326
      L-LDH-NAD; L-lactate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27888.1

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