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    pgp-1 Multidrug resistance protein pgp-1 [ Caenorhabditis elegans ]

    Gene ID: 178215, updated on 2-Nov-2024

    Summary

    Official Symbol
    pgp-1
    Official Full Name
    Multidrug resistance protein pgp-1
    Primary source
    WormBase:WBGene00003995
    Locus tag
    CELE_K08E7.9
    See related
    AllianceGenome:WB:WBGene00003995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in defense response to other organism; response to metal ion; and response to nematicide. Located in apical plasma membrane. Is expressed in intestine and pharynx. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See pgp-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    14
    Sequence:
    Chromosome: IV; NC_003282.8 (12591704..12599169, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat domain-containing protein Neighboring gene Cullin-6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene G-patch domain-containing protein Neighboring gene Exchange factor for Arf-6

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ABC-type xenobiotic transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables efflux transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in innate immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to metal ion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to nematicide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in siderophore transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in siderophore-dependent iron import into cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Multidrug resistance protein pgp-1
    NP_502413.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12591704..12599169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070012.6NP_502413.1  Multidrug resistance protein pgp-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502413.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34712, Q21349
      Conserved Domains (1) summary
      PTZ00265
      Location:381311
      PTZ00265; multidrug resistance protein (mdr1); Provisional