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    tep-1 TEP (ThiolEster containing Protein) [ Caenorhabditis elegans ]

    Gene ID: 173367, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tep-1
    Official Full Name
    TEP (ThiolEster containing Protein)
    Primary source
    WormBase:WBGene00013969
    Locus tag
    CELE_ZK337.1
    See related
    AllianceGenome:WB:WBGene00013969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable endopeptidase inhibitor activity. Predicted to be located in extracellular space. Is expressed in hypodermis; nervous system; and reproductive system. Orthologous to human CD109 (CD109 molecule). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See tep-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    18
    Sequence:
    Chromosome: I; NC_003279.8 (14994581..15001691)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DBD_Tnp_Mut domain-containing protein Neighboring gene pseudo Neighboring gene Protein mtd-1 Neighboring gene DNA polymerase epsilon catalytic subunit Neighboring gene Regulator of microtubule dynamics protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A large repertoire of parasite epitopes matched by a large repertoire of host immune receptors in an invertebrate host/parasite model. Moné Y, et al. PLoS Negl Trop Dis, 2010 Sep 7. PMID 20838648, Free PMC Article
    2. C. elegans BLMP-1 controls apical epidermal cell morphology by repressing expression of mannosyltransferase bus-8 and molting signal mlt-8. Wu YZ, et al. Dev Biol, 2022 Jun. PMID 35367457
    3. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
    4. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TEP (ThiolEster containing Protein)
    NP_001366904.1
    • Product from WormBase gene class tep;
      Confirmed by transcript evidence
    NP_001367060.1
    • Product from WormBase gene class tep;
      Confirmed by transcript evidence
    NP_001379225.1
    • Product from WormBase gene class tep;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14994581..15001691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392981.1 → NP_001379225.1  TEP (ThiolEster containing Protein) [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JKM0
      Conserved Domains (5) summary
      COG2373
      Location:100 → 1308
      YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
      cd02897
      Location:970 → 1261
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:750 → 840
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1365 → 1454
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:495 → 631
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    2. NM_001381277.1 → NP_001367060.1  TEP (ThiolEster containing Protein) [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YTU0
      Conserved Domains (5) summary
      COG2373
      Location:100 → 1316
      YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
      cd02897
      Location:978 → 1269
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:758 → 848
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1373 → 1462
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:495 → 631
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    3. NM_001381276.2 → NP_001366904.1  TEP (ThiolEster containing Protein) [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46014, O46015
      Conserved Domains (5) summary
      COG2373
      Location:100 → 1319
      YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
      cd02897
      Location:981 → 1272
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:761 → 851
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1376 → 1465
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:495 → 631
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein
    Heading Accession and Version

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