tax-2 Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tax-2
Official Full Name: Cyclic nucleotide-binding domain-containing protein
Primary source: WormBase:WBGene00006525
Locus tag: CELE_F36F2.5
See related: AllianceGenome:WB:WBGene00006525
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Contributes to intracellularly cGMP-activated cation channel activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; positive regulation of macromolecule biosynthetic process; and thermosensory behavior. Part of cation channel complex. Is expressed in hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in achromatopsia 3; color blindness; retinitis pigmentosa; and retinitis pigmentosa 45. Orthologous to human CNGB1 (cyclic nucleotide gated channel subunit beta 1) and CNGB3 (cyclic nucleotide gated channel subunit beta 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tax-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 14

Sequence:: Chromosome: I; NC_003279.8 (9020945..9025608)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caenorhabditis elegans display a slow aversion to osmotic upshifts. This behavior requires the cGMP-gated sensory channel subunit TAX-2.
Title: An Aversive Response to Osmotic Upshift in Caenorhabditis elegans.
The results suggest that sensory transduction genes tax-4 and tax-2 are necessary for the proper assembly of presynapses.
Title: Sensory transduction channel subunits, tax-4 and tax-2, modify presynaptic molecular architecture in C. elegans.
By recording from the C. elegans thermosensory neurons AFD in vivo, we found that ion channels TAX-2 and TAX-4 are involved in temperature sensing by a cGMP-mediated pathway
Title: Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans.
Mutants in tax-2 showed abnormal thermal responses, suggesting that these genes are involved in warm avoidance.
Title: Distribution and movement of Caenorhabditis elegans on a thermal gradient.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F36F2.1 (e-PCR)
- UniSTS:316746

F36F2.5 (e-PCR)
- UniSTS:307607

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cGMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cAMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to intracellularly cGMP-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aerotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cGMP-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hyperoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxygen levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cation channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of intracellular cyclic nucleotide activated cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cyclic nucleotide-binding domain-containing protein

NP_492427.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9020945..9025608

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060026.6 → NP_492427.3 Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492427.3

Status: REVIEWED

UniProtKB/TrEMBL

G5EEE2, P90975

Conserved Domains (2) summary

cd00038
Location:538 → 652

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:221 → 467

Ion_trans; Ion transport protein