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    unc-97 LIM domain-containing protein unc-97 [ Caenorhabditis elegans ]

    Gene ID: 180827, updated on 2-Nov-2024

    Summary

    Official Symbol
    unc-97
    Official Full Name
    LIM domain-containing protein unc-97
    Primary source
    WormBase:WBGene00006826
    Locus tag
    CELE_F14D12.2
    See related
    AllianceGenome:WB:WBGene00006826
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables myosin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of sarcomere organization; and sensory perception of mechanical stimulus. Located in several cellular components, including adherens junction; basal plasma membrane; and contractile muscle fiber. Is expressed in body wall musculature; neurons; and non-striated muscle. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2W. Orthologous to human LIMS1 (LIM zinc finger domain containing 1) and LIMS2 (LIM zinc finger domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See unc-97 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (5593133..5594965)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Band 7 domain-containing protein;Mechanosensory protein 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene STAS domain-containing protein Neighboring gene ncRNA

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in M band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    LIM domain-containing protein unc-97
    NP_508943.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5593133..5594965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076542.8NP_508943.3  LIM domain-containing protein unc-97 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508943.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P50464
      Conserved Domains (5) summary
      cd09331
      Location:2179
      LIM1_PINCH; The first LIM domain of protein PINCH
      cd09332
      Location:82133
      LIM2_PINCH; The second LIM domain of protein PINCH
      cd09333
      Location:146197
      LIM3_PINCH; The third LIM domain of protein PINCH
      cd09334
      Location:203256
      LIM4_PINCH; The fourth LIM domain of protein PINCH
      cd09335
      Location:264317
      LIM5_PINCH; The fifth LIM domain of protein PINCH