nduf-7 putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nduf-7
Official Full Name: putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Primary source: WormBase:WBGene00012376
Locus tag: CELE_W10D5.2
See related: AllianceGenome:WB:WBGene00012376
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in aerobic respiration; electron transport coupled proton transport; and mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex I. Is expressed in anal depressor muscle; body wall musculature; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in developmental disorder of mental health and nuclear type mitochondrial complex I deficiency 3. Orthologous to human NDUFS7 (NADH:ubiquinone oxidoreductase core subunit S7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nduf-7 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (9108173..9110607, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The nduf-7(et19) mutant allele causes an increase in reactive oxygen species that activate ATFS-1, hence UPR(mt)-mediated statin resistance, and extends life span via CED-4.
Title: A Mutation in Caenorhabditis elegans NDUF-7 Activates the Mitochondrial Stress Response and Prolongs Lifespan via ROS and CED-4.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W10D5.2 (e-PCR)
- UniSTS:320380

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables NADH dehydrogenase (ubiquinone) activity	IBA Inferred from Biological aspect of Ancestor more info
enables NADH dehydrogenase (ubiquinone) activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables quinone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IBA Inferred from Biological aspect of Ancestor more info
involved_in electron transport coupled proton transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IC Inferred by Curator more info
involved_in mitochondrial respiratory chain complex I assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

NP_492445.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9108173..9110607 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060044.7 → NP_492445.1 putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492445.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94360

Conserved Domains (1) summary

PRK06411
Location:50 → 198

PRK06411; NADH dehydrogenase subunit B; Validated