U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    immt-1 MICOS complex subunit MIC60-1 [ Caenorhabditis elegans ]

    Gene ID: 180566, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    immt-1
    Official Full Name
    MICOS complex subunit MIC60-1
    Primary source
    WormBase:WBGene00020511
    Locus tag
    CELE_T14G11.3
    See related
    AllianceGenome:WB:WBGene00020511
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in cristae formation and response to reactive oxygen species. Located in mitochondrial inner membrane. Part of proton-transporting ATP synthase complex. Orthologous to human IMMT (inner membrane mitochondrial protein). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See immt-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (2682754..2687184, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Membrane-associated protein Neighboring gene TNFR-Cys domain-containing protein Neighboring gene Ig-like domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca(2+) overload in Caenorhabditis elegans. Wu X, et al. NPJ Aging, 2023 Aug 1. PMID 37528117, Free PMC Article
    2. A feedback loop engaging propionate catabolism intermediates controls mitochondrial morphology. Zhou J, et al. Nat Cell Biol, 2022 Apr. PMID 35418624
    3. Caenorhabditis elegans mitofilin homologs control the morphology of mitochondrial cristae and influence reproduction and physiology. Mun JY, et al. J Cell Physiol, 2010 Sep. PMID 20578245
    4. A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans. Head BP, et al. Mol Biol Cell, 2011 Mar 15. PMID 21248201, Free PMC Article
    5. RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans. Akay A, et al. Open Biol, 2013 Nov 20. PMID 24258276, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that the two C. elegans mitofilin isoforms, immt-1 and -2, have non-overlapping functions in controlling mitochondrial cristae formation.
      Title: Caenorhabditis elegans mitofilin homologs control the morphology of mitochondrial cristae and influence reproduction and physiology.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    MICOS complex subunit MIC60-1
    NP_508475.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2682754..2687184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076074.8 → NP_508475.2  MICOS complex subunit MIC60-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508475.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22505
      Conserved Domains (1) summary
      pfam09731
      Location:64 → 671
      Mitofilin; Mitochondrial inner membrane protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22505.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools