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    RIM2 Rim2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852491, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RIM2
    Official Full Name
    Rim2p
    Primary source
    SGD:S000000396
    Locus tag
    YBR192W
    See related
    AllianceGenome:SGD:S000000396; FungiDB:YBR192W; VEuPathDB:YBR192W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PYT1
    Summary
    Enables pyrimidine nucleotide transmembrane transporter activity. Involved in several processes, including metal ion transport; mitochondrial genome maintenance; and pyrimidine nucleotide transport. Located in mitochondrion. Used to study familial hyperinsulinemic hypoglycemia 8. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 8. Orthologous to human SLC25A33 (solute carrier family 25 member 33) and SLC25A36 (solute carrier family 25 member 36). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RIM2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (607652..608785)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S9B Neighboring gene ribosomal 60S subunit protein L21A Neighboring gene Med8p Neighboring gene Aim4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Splitting the functions of Rim2, a mitochondrial iron/pyrimidine carrier. Knight SAB, et al. Mitochondrion, 2019 Jul. PMID 30660752, Free PMC Article
    2. Identification of a mitochondrial transporter for pyrimidine nucleotides in Saccharomyces cerevisiae: bacterial expression, reconstitution and functional characterization. Marobbio CM, et al. Biochem J, 2006 Jan 15. PMID 16194150, Free PMC Article
    3. Overexpression of a novel member of the mitochondrial carrier family rescues defects in both DNA and RNA metabolism in yeast mitochondria. Van Dyck E, et al. Mol Gen Genet, 1995 Feb 20. PMID 7891656
    4. The mitochondrial carrier Rim2 co-imports pyrimidine nucleotides and iron. Froschauer EM, et al. Biochem J, 2013 Oct 1. PMID 23800229
    5. Genetic dissection of a mitochondria-vacuole signaling pathway in yeast reveals a link between chronic oxidative stress and vacuolar iron transport. Li L, et al. J Biol Chem, 2010 Apr 2. PMID 20139087, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mitochondrial iron transport and pyrimidine transport by Rim2 occur separately and independently. Rim2 could be a bifunctional carrier protein.
      Title: Splitting the functions of Rim2, a mitochondrial iron/pyrimidine carrier.
    2. In the absence of the main iron transporters Mrs3 and Mrs4, Rim2 carrier can supply the mitochondrial matrix with iron in a pyrimidine-nucleotide-dependent fashion.
      Title: The mitochondrial carrier Rim2 co-imports pyrimidine nucleotides and iron.
    3. Rim2 is a pyrimidine exchanger with an additional unique function in promoting mitochondrial iron utilization
      Title: Rim2, a pyrimidine nucleotide exchanger, is needed for iron utilization in mitochondria.
    4. Rim2p has been identified as a yeast mitochondrial pyrimidine nucleotide transporter
      Title: Identification of a mitochondrial transporter for pyrimidine nucleotides in Saccharomyces cerevisiae: bacterial expression, reconstitution and functional characterization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables pyrimidine nucleotide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrimidine nucleotide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyrimidine nucleotide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in metal ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial genome maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial genome maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleotide import into mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine nucleotide transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rim2p
    NP_009751.1
    • Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      607652..608785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178540.1 → NP_009751.1  TPA: Rim2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009751.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQI6, P38127
      UniProtKB/TrEMBL
      A6ZLD2, B3LMX0, C7GKF1, D3UET6, G2W9J3, N1P8M6
      Conserved Domains (2) summary
      PTZ00169
      Location:72 → 264
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:294 → 377
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38127.1

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