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    BUD20 Bud20p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850763, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BUD20
    Official Full Name
    Bud20p
    Primary source
    SGD:S000004064
    Locus tag
    YLR074C
    See related
    AllianceGenome:SGD:S000004064; FungiDB:YLR074C; VEuPathDB:YLR074C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ribosomal large subunit binding activity. Involved in ribosomal large subunit export from nucleus. Located in cytoplasm and nucleus. Part of preribosome, large subunit precursor. Orthologous to human ZNF593 (zinc finger protein 593). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See BUD20 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (281956..282456, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Lam6p Neighboring gene Rfu1p Neighboring gene ribosomal 60S subunit protein L10 Neighboring gene Fmp25p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes. Olombrada M, et al. Nucleic Acids Res, 2020 Jun 19. PMID 32365182, Free PMC Article
    2. The L1 stalk is required for efficient export of nascent large ribosomal subunits in yeast. Musalgaonkar S, et al. RNA, 2019 Nov. PMID 31439809, Free PMC Article
    3. The genomic landscape of compensatory evolution. Szamecz B, et al. PLoS Biol, 2014 Aug. PMID 25157590, Free PMC Article
    4. Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly. Micic J, et al. Nat Commun, 2020 Jul 27. PMID 32719344, Free PMC Article
    5. Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Zhou Y, et al. Nat Commun, 2019 Feb 27. PMID 30814529, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal large subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ribosomal large subunit export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bud20p
    NP_013175.1
    • C2H2-type zinc finger protein required for ribosome assembly; shuttling factor which associates with pre-60S particles in the nucleus, accompanying them to the cytoplasm; cytoplasmic dissociation of Bud20p requires Drg1p; N-terminus harbors a nuclear localization signal (NLS) and a nuclear export signal (NES); cytoplasmic Bud20p is reimported by Kap123-dependent pathway; involved in bud-site selection; diploid mutants display a random budding pattern; similar to human ZNF593

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      281956..282456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181961.1 → NP_013175.1  TPA: Bud20p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013175.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY75, Q08004
      UniProtKB/TrEMBL
      C7GQP9, G2WIR6, N1P6F1
      Conserved Domains (1) summary
      COG5112
      Location:1 → 133
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08004.1

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