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    BOS1 Bos1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850767, updated on 2-Nov-2024

    Summary

    Official Symbol
    BOS1
    Official Full Name
    Bos1p
    Primary source
    SGD:S000004068
    Locus tag
    YLR078C
    See related
    AllianceGenome:SGD:S000004068; FungiDB:YLR078C; VEuPathDB:YLR078C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SEC32
    Summary
    Enables SNAP receptor activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Located in ER to Golgi transport vesicle membrane and endoplasmic reticulum membrane. Part of SNARE complex. Used to study progressive myoclonus epilepsy 6. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 6. Orthologous to human GOSR2 (golgi SNAP receptor complex member 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See BOS1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    2
    Sequence:
    Chromosome: XII; NC_001144.5 (285736..286559, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L10 Neighboring gene Fmp25p Neighboring gene cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1 Neighboring gene Emp46p

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle fusion with Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ER to Golgi transport vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Bos1p
    NP_013179.1
    • v-SNARE (vesicle specific SNAP receptor); localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; required for efficient nuclear fusion during mating

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      285736..286559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181965.1NP_013179.1  TPA: Bos1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013179.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY78, P25385
      UniProtKB/TrEMBL
      A7A0Y2, C8ZD49, G2WIR9
      Conserved Domains (1) summary
      cd15863
      Location:152217
      SNARE_GS27; SNARE motif of GS27