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    SIC1 cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850768, updated on 3-Nov-2024

    Summary

    Official Symbol
    SIC1
    Official Full Name
    cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1
    Primary source
    SGD:S000004069
    Locus tag
    YLR079W
    See related
    AllianceGenome:SGD:S000004069; FungiDB:YLR079W; VEuPathDB:YLR079W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BYC1; SDB25
    Summary
    Enables cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in G1/S transition of mitotic cell cycle and negative regulation of macroautophagy. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See SIC1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (286820..287674)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Fmp25p Neighboring gene Bos1p Neighboring gene Emp46p Neighboring gene galactose permease GAL2

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1
    NP_013180.1
    • Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylated by Clb5/6-Cdk1 and Cln1/2-Cdk1 kinase which regulate timing of Sic1p degradation; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      286820..287674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181966.1NP_013180.1  TPA: cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013180.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY79, P38634
      UniProtKB/TrEMBL
      B3LT47, B5VN11, G2WIS0, N1P6F6