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    GAL2 galactose permease GAL2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850770, updated on 14-Nov-2024

    Summary

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    Official Symbol
    GAL2
    Official Full Name
    galactose permease GAL2
    Primary source
    SGD:S000004071
    Locus tag
    YLR081W
    See related
    AllianceGenome:SGD:S000004071; FungiDB:YLR081W; VEuPathDB:YLR081W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables D-glucose transmembrane transporter activity and galactose transmembrane transporter activity. Involved in galactose metabolic process and galactose transmembrane transport. Located in plasma membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See GAL2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (290212..291936)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1 Neighboring gene Emp46p Neighboring gene Srl2p Neighboring gene Emp70p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolome, transcriptome and metabolic flux analysis of arabinose fermentation by engineered Saccharomyces cerevisiae. Wisselink HW, et al. Metab Eng, 2010 Nov. PMID 20816840
    2. Sequence and structure of the yeast galactose transporter. Szkutnicka K, et al. J Bacteriol, 1989 Aug. PMID 2666404, Free PMC Article
    3. Yeast galactose permease is related to yeast and mammalian glucose transporters. Nehlin JO, et al. Gene, 1989 Dec 28. PMID 2697639
    4. GAL2 codes for a membrane-bound subunit of the galactose permease in Saccharomyces cerevisiae. Tschopp JF, et al. J Bacteriol, 1986 Apr. PMID 3082856, Free PMC Article
    5. Germination conditions that require mitochondrial function in Saccharomyces cerevisiae: utilization of acetate and galactose. Donnini C, et al. J Bacteriol, 1986 Dec. PMID 3536869, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of a glucose-insensitive variant of Gal2 from Saccharomyces cerevisiae exhibiting a high pentose transport capacity.
      Title: Identification of a glucose-insensitive variant of Gal2 from Saccharomyces cerevisiae exhibiting a high pentose transport capacity.
    2. In this study, we show that the other components of SCF(Grr1), including Skp1, Rbx1p, and the ubiquitin-conjugating enzyme Cdc34, are also necessary for glucose-induced Gal2p degradation.
      Title: The ubiquitin ligase SCF(Grr1) is required for Gal2p degradation in the yeast Saccharomyces cerevisiae.
    3. The roles of GAL1 and GAL2 in the activation of the galactose metabolism network of S. cerevisiae are reported.
      Title: The regulatory roles of the galactose permease and kinase in the induction response of the GAL network in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in galactose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    galactose permease GAL2
    NP_013182.1
    • Galactose permease; required for utilization of galactose; also able to transport glucose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      290212..291936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181968.1 → NP_013182.1  TPA: galactose permease GAL2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013182.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY81, P13181, Q12521
      UniProtKB/TrEMBL
      B3LT49, B5VN13, C8ZD52, G2WIS2
      Conserved Domains (2) summary
      cd06174
      Location:75 → 518
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:74 → 534
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13181.3

    Gene LinkOut

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