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    EMP70 Emp70p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850772, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EMP70
    Official Full Name
    Emp70p
    Primary source
    SGD:S000004073
    Locus tag
    YLR083C
    See related
    AllianceGenome:SGD:S000004073; FungiDB:YLR083C; VEuPathDB:YLR083C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TMN1
    Summary
    Involved in several processes, including intracellular copper ion homeostasis; invasive growth in response to glucose limitation; and pseudohyphal growth. Located in endosome and fungal-type vacuole membrane. Orthologous to several human genes including TM9SF2 (transmembrane 9 superfamily member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EMP70 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (294091..296094, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene galactose permease GAL2 Neighboring gene Srl2p Neighboring gene Rax2p Neighboring gene Arp6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Partial purification and characterization of early and late endosomes from yeast. Identification of four novel proteins. Singer-Krüger B, et al. J Biol Chem, 1993 Jul 5. PMID 8314797
    2. Conserved function of the lysine-based KXD/E motif in Golgi retention for endomembrane proteins among different organisms. Woo CH, et al. Mol Biol Cell, 2015 Nov 15. PMID 26378254, Free PMC Article
    3. Transmembrane nine proteins in yeast and Arabidopsis affect cellular metal contents without changing vacuolar morphology. Hegelund JN, et al. Physiol Plant, 2010 Dec. PMID 20681974
    4. Characterization of a 76 kDa endosomal, multispanning membrane protein that is highly conserved throughout evolution. Schimmöller F, et al. Gene, 1998 Aug 31. PMID 9729438
    5. Control of cellular physiology by TM9 proteins in yeast and Dictyostelium. Froquet R, et al. J Biol Chem, 2008 Mar 14. PMID 18178563

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular copper ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular monoatomic cation homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pseudohyphal growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vacuolar transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Emp70p
    NP_013184.1
    • Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      294091..296094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181970.1 → NP_013184.1  TPA: Emp70p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013184.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY83, P32802, Q12101
      UniProtKB/TrEMBL
      A7A0Y7, B3LT51, C7GQQ7
      Conserved Domains (1) summary
      pfam02990
      Location:72 → 624
      EMP70; Endomembrane protein 70
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32802.2

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