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    RAX2 Rax2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850773, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RAX2
    Official Full Name
    Rax2p
    Primary source
    SGD:S000004074
    Locus tag
    YLR084C
    See related
    AllianceGenome:SGD:S000004074; FungiDB:YLR084C; VEuPathDB:YLR084C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in axial cellular bud site selection; bipolar cellular bud site selection; and protein localization. Located in cellular bud neck and cellular bud scar. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RAX2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (296589..300251, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Srl2p Neighboring gene Emp70p Neighboring gene Arp6p Neighboring gene condensin subunit SMC4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A three-hybrid screen identifies mRNAs controlled by a regulatory protein. Seay D, et al. RNA, 2006 Aug. PMID 16809817, Free PMC Article
    2. Multigenerational cortical inheritance of the Rax2 protein in orienting polarity and division in yeast. Chen T, et al. Science, 2000 Dec 8. PMID 11110666
    3. Subcellular localization of the interaction of bipolar landmarks Bud8p and Bud9p with Rax2p in Saccharomyces cerevisiae diploid cells. Kato Y, et al. Biochem Biophys Res Commun, 2010 Sep 3. PMID 20678480
    4. Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast. Kang PJ, et al. Mol Biol Cell, 2004 Nov. PMID 15356260, Free PMC Article
    5. Translational repression by PUF proteins in vitro. Chritton JJ, et al. RNA, 2010 Jun. PMID 20427513, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These observations suggest that the interaction of Rax2p with Bud8p and Bud9p may contribute to the translocation of bipolar landmarks to the correct sites.
      Title: Subcellular localization of the interaction of bipolar landmarks Bud8p and Bud9p with Rax2p in Saccharomyces cerevisiae diploid cells.
    2. Rax1p and Rax2p interact closely with each other and with Bud8p and Bud9p in the establishment and/or maintenance of the cortical landmarks for bipolar budding
      Title: Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in axial cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bipolar cellular bud site selection IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in bipolar cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular bud site selection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    is_active_in cellular bud neck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular bud scar IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud scar IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane of growing cell tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rax2p
    NP_013185.1
    • Protein required for the maintenance of bud site selection; localizes; localization to the bud neck and previous sites of cell division (bud scars; cytokinesis remnants (CRMs)) is interdependent with Rax2p; required with Rax1p to anchor both Nba1p and Nis1p to CRMs where a Cdc42p inhibitory zone is established preventing repolarization of cells at previous division sites; RAX2 mRNA stability is regulated by Mpt5p; predicted type I membrane-spanning protein; N-glycosylated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      296589..300251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181971.1 → NP_013185.1  TPA: Rax2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013185.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY84, Q12465
      UniProtKB/TrEMBL
      A7A0Y8, B3LT52, B5VN16
      Conserved Domains (1) summary
      pfam12768
      Location:976 → 1213
      Rax2; Cortical protein marker for cell polarity
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12465.1

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