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    SND2 Snd2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850754, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SND2
    Official Full Name
    Snd2p
    Primary source
    SGD:S000004055
    Locus tag
    YLR065C
    See related
    AllianceGenome:SGD:S000004055; FungiDB:YLR065C; VEuPathDB:YLR065C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ENV10
    Summary
    Involved in vacuolar protein processing. Located in endoplasmic reticulum. Orthologous to human TMEM208 (transmembrane protein 208). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SND2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (266373..266918, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene 25S rRNA (uracil2843-N3)-methyltransferase Neighboring gene Per33p Neighboring gene signal peptidase complex subunit SPC3 Neighboring gene Pet309p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Snd3 controls nucleus-vacuole junctions in response to glucose signaling. Tosal-Castano S, et al. Cell Rep, 2021 Jan 19. PMID 33472077
    2. ER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway. Xiao T, et al. Life Sci Alliance, 2021 Mar. PMID 33479049, Free PMC Article
    3. A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes involved in lysosomal vacuole function and morphology. Ricarte F, et al. PLoS One, 2011. PMID 21912603, Free PMC Article
    4. Genomewide analysis reveals novel pathways affecting endoplasmic reticulum homeostasis, protein modification and quality control. Copic A, et al. Genetics, 2009 Jul. PMID 19433630, Free PMC Article
    5. Chemogenetic E-MAP in Saccharomyces cerevisiae for Identification of Membrane Transporters Operating Lipid Flip Flop. Vazquez HM, et al. PLoS Genet, 2016 Jul. PMID 27462707, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Snd2p
    NP_013166.1
    • Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Pho88p/Snd3p and Sec61p-translocon subunits; can compensate for loss of SRP; role in the late endosome-vacuole interface; putative role in secretory protein quality control

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      266373..266918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181952.1 → NP_013166.1  TPA: Snd2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013166.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY66, Q6Q5C1, Q99382
      UniProtKB/TrEMBL
      A7A0X0, B3LT35, C7GQP0, C8ZD37, G2WIQ7, N1P6E2
      Conserved Domains (1) summary
      pfam05620
      Location:1 → 171
      DUF788; Protein of unknown function (DUF788)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99382.1

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