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    SPC3 signal peptidase complex subunit SPC3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850755, updated on 2-Nov-2024

    Summary

    Official Symbol
    SPC3
    Official Full Name
    signal peptidase complex subunit SPC3
    Primary source
    SGD:S000004056
    Locus tag
    YLR066W
    See related
    AllianceGenome:SGD:S000004056; FungiDB:YLR066W; VEuPathDB:YLR066W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein targeting to ER and signal peptide processing. Located in endoplasmic reticulum. Part of signal peptidase complex. Orthologous to human SPCS3 (signal peptidase complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See SPC3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (267169..267723)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Per33p Neighboring gene Snd2p Neighboring gene Pet309p Neighboring gene Fyv7p

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein targeting to ER IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal peptide processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal peptide processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of signal peptidase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of signal peptidase complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    signal peptidase complex subunit SPC3
    NP_013167.1
    • Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of the complex are Spc1p, Spc2p, and Sec11p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      267169..267723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181953.1NP_013167.1  TPA: signal peptidase complex subunit SPC3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013167.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY67, Q12133
      UniProtKB/TrEMBL
      A7A0X1, B3LT36, B5VMZ8, C7GQP1, C8ZD38, G2WIQ8, N1P108
      Conserved Domains (1) summary
      pfam04573
      Location:4177
      SPC22; Signal peptidase subunit