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    XYL2 D-xylulose reductase XYL2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850759, updated on 2-Nov-2024

    Summary

    Official Symbol
    XYL2
    Official Full Name
    D-xylulose reductase XYL2
    Primary source
    SGD:S000004060
    Locus tag
    YLR070C
    See related
    AllianceGenome:SGD:S000004060; FungiDB:YLR070C; VEuPathDB:YLR070C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables D-xylulose reductase activity. Involved in xylulose biosynthetic process. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See XYL2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (274141..275211, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Fyv7p Neighboring gene Mef1p Neighboring gene Rgr1p Neighboring gene Lam6p

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-xylulose reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables D-xylulose reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-iditol 2-dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in D-xylose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-arabinose catabolic process to xylulose 5-phosphate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sorbitol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in xylulose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    D-xylulose reductase XYL2
    NP_013171.1
    • Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      274141..275211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181957.1NP_013171.1  TPA: D-xylulose reductase XYL2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013171.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY71, Q07993
      UniProtKB/TrEMBL
      A7A0X5, B3LT40, B5VN02, C7GQP5, C8ZD42, G2WIR2, N1NZI2
      Conserved Domains (1) summary
      cd05285
      Location:9354
      sorbitol_DH; Sorbitol dehydrogenase