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    L-methionine (R)-S-oxide reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853794, updated on 9-Dec-2024

    Summary

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    Official Full Name
    L-methionine (R)-S-oxide reductase
    Primary source
    SGD:S000001552
    Locus tag
    YKL069W
    See related
    AllianceGenome:SGD:S000001552; FungiDB:YKL069W; VEuPathDB:YKL069W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YKG9
    Summary
    Enables L-methionine-(R)-S-oxide reductase activity. Involved in cellular response to oxidative stress. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (307285..307827)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Osi1p Neighboring gene uncharacterized protein Neighboring gene tRNA-Val Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cysteine-125 is the catalytic residue of Saccharomyces cerevisiae free methionine-R-sulfoxide reductase. Kwak GH, et al. Biochem Biophys Res Commun, 2010 May 7. PMID 20382110
    2. Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae. Le DT, et al. J Biol Chem, 2009 Feb 13. PMID 19049972, Free PMC Article
    3. Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast. Kaya A, et al. Biochemistry, 2010 Oct 5. PMID 20799725, Free PMC Article
    4. Dimethyl sulfoxide elevates hydrogen peroxide-mediated cell death in Saccharomyces cerevisiae by inhibiting the antioxidant function of methionine sulfoxide reductase A. Kwak GH, et al. BMB Rep, 2010 Sep. PMID 20846495
    5. Trapping redox partnerships in oxidant-sensitive proteins with a small, thiol-reactive cross-linker. Allan KM, et al. Free Radic Biol Med, 2016 Dec. PMID 27816612, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-methionine-(R)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-methionine-(R)-S-oxide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-methionine-(R)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    L-methionine (R)-S-oxide reductase
    NP_012854.1
    • Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; capable of binding and degrading patulin, a polyketide mycotoxin, forming E-ascladiol; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      307285..307827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179635.1 → NP_012854.1  TPA: L-methionine (R)-S-oxide reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012854.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXL7, P36088
      UniProtKB/TrEMBL
      A6ZZP6, B3LR21, B5VM88, C7GVN7, C8ZCA3, G2WHW2, N1NZ68
      Conserved Domains (1) summary
      COG1956
      Location:8 → 180
      GAF; GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36088.1

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