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    EFM3 protein-lysine N-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853593, updated on 14-Nov-2024

    Summary

    Official Symbol
    EFM3
    Official Full Name
    protein-lysine N-methyltransferase
    Primary source
    SGD:S000003890
    Locus tag
    YJR129C
    See related
    AllianceGenome:SGD:S000003890; FungiDB:YJR129C; VEuPathDB:YJR129C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine trimethylation. Located in cytoplasm. Orthologous to several human genes including EEF2KMT (eukaryotic elongation factor 2 lysine methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See EFM3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (664000..665019, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Rsf2p Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene cystathionine gamma-synthase Neighboring gene mannosyl-oligosaccharide 1,2-alpha-mannosidase

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm  

    General protein information

    Preferred Names
    protein-lysine N-methyltransferase
    NP_012663.2
    • S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which trimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 509; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; ortholog of human gene FAM86A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      664000..665019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181787.2 → NP_012663.2  TPA: protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012663.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWU7, P47163
      UniProtKB/TrEMBL
      A6ZQ84, B3LQL1, N1P0A5
      Conserved Domains (1) summary
      cl17173
      Location:137 → 286
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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