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    STE24 zinc metalloprotease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853581, updated on 2-Nov-2024

    Summary

    Official Symbol
    STE24
    Official Full Name
    zinc metalloprotease
    Primary source
    SGD:S000003878
    Locus tag
    YJR117W
    See related
    AllianceGenome:SGD:S000003878; FungiDB:YJR117W; VEuPathDB:YJR117W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AFC1; PIO2
    Summary
    Enables metalloendopeptidase activity. Involved in several processes, including negative regulation of post-translational protein targeting to membrane, translocation; post-translational protein targeting to membrane, translocation; and protein maturation. Located in endoplasmic reticulum membrane and nuclear inner membrane. Used to study metabolic dysfunction-associated steatotic liver disease; progeria; restrictive dermopathy; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy; progeria; restrictive dermopathy; and restrictive dermopathy 1. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See STE24 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (642007..643368)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tda4p Neighboring gene Ilm1p Neighboring gene histone demethylase

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in CAAX-box protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in CAAX-box protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in CAAX-box protein processing IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in CAAX-box protein processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ERAD pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of post-translational protein targeting to membrane, translocation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in post-translational protein targeting to membrane, translocation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in post-translational protein targeting to membrane, translocation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane HDA PubMed 
    located_in nuclear inner membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc metalloprotease
    NP_012651.1
    • Highly conserved zinc metalloprotease; component of the ER quality control mechanism that removes faulty proteins clogging translocation channels; inhibits SRP-independent translocation into the ER; has two roles in a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves isoprenylated and non-prenylated oligopeptides; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and complements the null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      642007..643368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181775.1NP_012651.1  TPA: zinc metalloprotease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012651.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWT6, P47154
      UniProtKB/TrEMBL
      B5VLQ9, C7GM94, G2WHC0, N1P3N5
      Conserved Domains (1) summary
      cd07343
      Location:17446
      M48A_Zmpste24p_like; Peptidase M48 subfamily A, a type 1 CaaX endopeptidase