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    KCH1 Kch1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KCH1
    Official Full Name
    Kch1p
    Primary source
    SGD:S000003815
    Locus tag
    YJR054W
    See related
    AllianceGenome:SGD:S000003815; FungiDB:YJR054W; VEuPathDB:YJR054W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables potassium ion transmembrane transporter activity. Involved in potassium ion transmembrane transport. Located in mating projection and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KCH1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (536056..537549)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene UV-damaged DNA-binding protein RAD7 Neighboring gene Bfa1p Neighboring gene tRNA-Arg Neighboring gene Hit1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kch1 family proteins mediate essential responses to endoplasmic reticulum stresses in the yeasts Saccharomyces cerevisiae and Candida albicans. Stefan CP, et al. J Biol Chem, 2013 Nov 29. PMID 24142703, Free PMC Article
    2. Yeast Kch1 and Kch2 membrane proteins play a pleiotropic role in membrane potential establishment and monovalent cation homeostasis regulation. Felcmanova K, et al. FEMS Yeast Res, 2017 Aug 1. PMID 28810704
    3. Activation of an essential calcium signaling pathway in Saccharomyces cerevisiae by Kch1 and Kch2, putative low-affinity potassium transporters. Stefan CP, et al. Eukaryot Cell, 2013 Feb. PMID 23204190, Free PMC Article
    4. ER-associated retrograde SNAREs and the Dsl1 complex mediate an alternative, Sey1p-independent homotypic ER fusion pathway. Rogers JV, et al. Mol Biol Cell, 2014 Nov 1. PMID 25187651, Free PMC Article
    5. SWR1 chromatin remodeling complex prevents mitotic slippage during spindle position checkpoint arrest. Caydasi AK, et al. Mol Biol Cell, 2023 Feb 1. PMID 36542480, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data demonstrate that the Kch1 and Kch2 proteins significantly contribute to the maintenance of optimal cation homeostasis and membrane potential in Saccharomyces cerevisiae but not in Candida albicans.
      Title: Yeast Kch1 and Kch2 membrane proteins play a pleiotropic role in membrane potential establishment and monovalent cation homeostasis regulation.
    2. Kch1 family proteins represent a conserved linkage between HACS and only certain classes of ER stress in these yeasts.
      Title: Kch1 family proteins mediate essential responses to endoplasmic reticulum stresses in the yeasts Saccharomyces cerevisiae and Candida albicans.
    3. Kch1 and Kch2 directly promote potassium influx and calcium signaling may electrochemically respond to potassium influx.
      Title: Activation of an essential calcium signaling pathway in Saccharomyces cerevisiae by Kch1 and Kch2, putative low-affinity potassium transporters.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables potassium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in mating projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kch1p
    NP_012588.1
    • Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; localized to sites of polarized growth; member of a fungal-specific gene family; potential Cdc28p substrate; KCH1 has a paralog, PRM6, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      536056..537549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181712.1 → NP_012588.1  TPA: Kch1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012588.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWM5, P47114
      UniProtKB/TrEMBL
      B5VLK9, G2WH59
      Conserved Domains (1) summary
      pfam16944
      Location:14 → 266
      KCH; Fungal potassium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47114.1

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