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    SYS1 Sys1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SYS1
    Official Full Name
    Sys1p
    Primary source
    SGD:S000003541
    Locus tag
    YJL004C
    See related
    AllianceGenome:SGD:S000003541; FungiDB:YJL004C; VEuPathDB:YJL004C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in Golgi to endosome transport; Golgi to plasma membrane protein transport; and protein localization to Golgi apparatus. Located in Golgi membrane and trans-Golgi network. Orthologous to human SYS1 (SYS1 golgi trafficking protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SYS1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (431589..432200, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene adenylate cyclase Neighboring gene Cox16p Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An acidic sequence of a putative yeast Golgi membrane protein binds COPII and facilitates ER export. Votsmeier C, et al. EMBO J, 2001 Dec 3. PMID 11726510, Free PMC Article
    2. Isolation and characterization of SYS genes from yeast, multicopy suppressors of the functional loss of the transport GTPase Ypt6p. Tsukada M, et al. J Cell Sci, 1996 Oct. PMID 8923208
    3. Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p. Setty SR, et al. Nat Cell Biol, 2004 May. PMID 15077114
    4. Arl1p is involved in transport of the GPI-anchored protein Gas1p from the late Golgi to the plasma membrane. Liu YW, et al. J Cell Sci, 2006 Sep 15. PMID 16926193
    5. Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles. Miller EA, et al. Cell, 2003 Aug 22. PMID 12941277

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to endosome transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sys1p
    NP_012530.1
    • Integral membrane protein of the Golgi; required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      431589..432200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181438.1 → NP_012530.1  TPA: Sys1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012530.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWH1, P41544
      UniProtKB/TrEMBL
      A6ZPW3, B3LQ95, C7GUU3, D3UF65, G2WH06, N1P8L1
      Conserved Domains (1) summary
      pfam09801
      Location:20 → 163
      SYS1; Integral membrane protein S linking to the trans Golgi network
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41544.1

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