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    ARG3 ornithine carbamoyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853357, updated on 9-Dec-2024

    Summary

    Official Symbol
    ARG3
    Official Full Name
    ornithine carbamoyltransferase
    Primary source
    SGD:S000003624
    Locus tag
    YJL088W
    See related
    AllianceGenome:SGD:S000003624; FungiDB:YJL088W; VEuPathDB:YJL088W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ornithine carbamoyltransferase activity. Involved in L-arginine biosynthetic process. Located in cytosol. Used to study ornithine carbamoyltransferase deficiency. Human ortholog(s) of this gene implicated in ornithine carbamoyltransferase deficiency. Orthologous to human OTC (ornithine transcarbamylase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ARG3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (268799..269815)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene protein kinase activating protein DPB11 Neighboring gene Sip4p Neighboring gene tRNA ligase Neighboring gene GTP-Rho binding exocyst subunit EXO70

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_001142.9

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables amino acid binding  
    enables carboxyl- or carbamoyltransferase activity  
    enables ornithine carbamoyltransferase activity  
    enables ornithine carbamoyltransferase activity PubMed 
    enables ornithine carbamoyltransferase activity  
    enables transferase activity  
    Process Evidence Code Pubs
    involved_in L-arginine biosynthetic process  
    involved_in L-arginine biosynthetic process PubMed 
    involved_in amino acid metabolic process  
    involved_in arginine biosynthetic process via ornithine  
    involved_in citrulline biosynthetic process  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol PubMed 
    is_active_in mitochondrion  

    General protein information

    Preferred Names
    ornithine carbamoyltransferase
    NP_012447.1
    • Ornithine carbamoyltransferase; also known as carbamoylphosphate:L-ornithine carbamoyltransferase; catalyzes the biosynthesis of the arginine precursor citrulline

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      268799..269815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181521.1 → NP_012447.1  TPA: ornithine carbamoyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012447.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW96, P05150
      UniProtKB/TrEMBL
      A6ZPN7, B3LQ25, C7GR26, C8ZBC5, G2WGT0, N1NZT4
      Conserved Domains (1) summary
      cl39061
      Location:12 → 329
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
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