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    SCP160 Scp160p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853365, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SCP160
    Official Full Name
    Scp160p
    Primary source
    SGD:S000003616
    Locus tag
    YJL080C
    See related
    AllianceGenome:SGD:S000003616; FungiDB:YJL080C; VEuPathDB:YJL080C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables G-protein alpha-subunit binding activity and mRNA binding activity. Involved in several processes, including chemotropism; constitutive heterochromatin formation; and pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in endoplasmic reticulum membrane. Orthologous to human HDLBP (high density lipoprotein binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SCP160 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (285558..289226, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Iml2p Neighboring gene Arp4p Neighboring gene sterol-binding protein Neighboring gene Pry3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Scp160p, an RNA-binding, polysome-associated protein, localizes to the endoplasmic reticulum of Saccharomyces cerevisiae in a microtubule-dependent manner. Frey S, et al. J Biol Chem, 2001 May 11. PMID 11278502
    2. Scp160p, a new yeast protein associated with the nuclear membrane and the endoplasmic reticulum, is necessary for maintenance of exact ploidy. Wintersberger U, et al. Yeast, 1995 Aug. PMID 8533468
    3. Analysis of a predicted nuclear localization signal: implications for the intracellular localization and function of the Saccharomyces cerevisiae RNA-binding protein Scp160. Brykailo MA, et al. Nucleic Acids Res, 2007. PMID 17933776, Free PMC Article
    4. Purification and nucleic-acid-binding properties of a Saccharomyces cerevisiae protein involved in the control of ploidy. Weber V, et al. Eur J Biochem, 1997 Oct 1. PMID 9363784
    5. Functional overlap between conserved and diverged KH domains in Saccharomyces cerevisiae SCP160. Brykailo MA, et al. Nucleic Acids Res, 2007. PMID 17264125, Free PMC Article

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Scp160-dependent mRNA trafficking mediates pheromone gradient sensing and chemotropism in yeast.
      Title: Scp160-dependent mRNA trafficking mediates pheromone gradient sensing and chemotropism in yeast.
    2. SESA network comprising Smy2, Eap1, Scp160 and Asc1 , specifically inhibits initiation of translation of POM34 mRNA that encodes an integral membrane protein of the nuclear pore complex
      Title: The SESA network links duplication of the yeast centrosome with the protein translation machinery.
    3. Results indicate that key basic residues within the predicted nuclear localization signal of Scp160 can be altered without severely affecting Scp160 function.
      Title: Analysis of a predicted nuclear localization signal: implications for the intracellular localization and function of the Saccharomyces cerevisiae RNA-binding protein Scp160.
    4. Both conserved and diverged KH domains are essential for Scp160 function.
      Title: Functional overlap between conserved and diverged KH domains in Saccharomyces cerevisiae SCP160.
    5. Scp160p contributes to silencing by helping telomere clustering
      Title: The multi-KH domain protein of Saccharomyces cerevisiae Scp160p contributes to the regulation of telomeric silencing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemotropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic telomere clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Scp160p
    NP_012455.1
    • Essential RNA-binding G protein effector of mating response pathway; ligand-activated RNA-binding protein that delivers RNAs involved in polarization and perpetualizing mating signal to shmoo tip during pheromone signaling; Scp160p-mediated RNA trafficking essential for chemotropism and successful mating; mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      285558..289226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181513.1 → NP_012455.1  TPA: Scp160p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012455.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWA3, P06105
      UniProtKB/TrEMBL
      C8ZBD2, N1P334
      Conserved Domains (9) summary
      TIGR01612
      Location:170 → 402
      235kDa-fam; reticulocyte binding/rhoptry protein
      cd22446
      Location:172 → 257
      KH-I_ScSCP160_rpt1; first type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
      cd22447
      Location:632 → 707
      KH-I_ScSCP160_rpt2; second type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
      cd22448
      Location:711 → 777
      KH-I_ScSCP160_rpt3; third type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
      cd22449
      Location:780 → 857
      KH-I_ScSCP160_rpt4; fourth type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
      cd22450
      Location:859 → 935
      KH-I_ScSCP160_rpt5; fifth type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
      cd22451
      Location:940 → 1008
      KH-I_ScSCP160_rpt6; sixth type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
      cd22452
      Location:1152 → 1218
      KH-I_ScSCP160_rpt7; seventh type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
      cl11394
      Location:502 → 606
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06105.3

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