GCG1 gamma-glutamylcyclotransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GCG1
Official Full Name: gamma-glutamylcyclotransferase
Primary source: SGD:S000000965
Locus tag: YER163C
See related: AllianceGenome:SGD:S000000965; FungiDB:YER163C; VEuPathDB:YER163C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables gamma-glutamylcyclotransferase activity. Involved in glutathione catabolic process. Located in cytoplasm and nucleus. Orthologous to human CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1) and CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GCG1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (503084..503782, complement)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables gamma-glutamylcyclotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione specific gamma-glutamylcyclotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione specific gamma-glutamylcyclotransferase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutathione catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gamma-glutamylcyclotransferase

NP_011090.3

EC 4.3.2.7

Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

503084..503782 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179053.3 → NP_011090.3 TPA: gamma-glutamylcyclotransferase [Saccharomyces cerevisiae S288C]

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DM71, P32656

UniProtKB/TrEMBL

A6ZRB9, B3LRS4, C7GS47, C8Z7I5, G2WD49, N1P3P1

Conserved Domains (1) summary

pfam04752
Location:8 → 231

ChaC; ChaC-like protein