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    MMS22 Mms22p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851030, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MMS22
    Official Full Name
    Mms22p
    Primary source
    SGD:S000004312
    Locus tag
    YLR320W
    See related
    AllianceGenome:SGD:S000004312; FungiDB:YLR320W; VEuPathDB:YLR320W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SLM2
    Summary
    Involved in DNA metabolic process and meiotic sister chromatid segregation. Located in nucleus. Part of Cul8-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MMS22 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (771940..776304)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene telomerase reverse transcriptase Neighboring gene Bud6p Neighboring gene Sfh1p Neighboring gene U2-type spliceosomal complex subunit CWC24

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genes required for ionizing radiation resistance in yeast. Bennett CB, et al. Nat Genet, 2001 Dec. PMID 11726929
    2. Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage. Duro E, et al. DNA Repair (Amst), 2008 May 3. PMID 18321796
    3. Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II. Baldwin EL, et al. Nucleic Acids Res, 2005. PMID 15718301, Free PMC Article
    4. Mms1 and Mms22 stabilize the replisome during replication stress. Vaisica JA, et al. Mol Biol Cell, 2011 Jul 1. PMID 21593207, Free PMC Article
    5. Parental histone deposition on the replicated strands promotes error-free DNA damage tolerance and regulates drug resistance. Dolce V, et al. Genes Dev, 2022 Feb 1. PMID 35115379, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The DNA repair protein Mms22 is required for double strand break repair, and recruited to chromatin in a ubiquitin-dependent manner as a result of DNA damage.
      Title: Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair.
    2. cells lacking MMS22 have severly defective recombination between sister chromatids or between homologous chromosomes induced by agents that block replisomes and are defective in recovery from Methylmethane Sulfonate-induced replisome stalling
      Title: Budding yeast Mms22 and Mms1 regulate homologous recombination induced by replisome blockage.
    3. Mms22p protects cells from topoisomerase II-mediated DNA damage.
      Title: Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in recombinational repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul8-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul8-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cul8-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mms22p
    NP_013424.1
    • Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of replication fork, such as fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; Rtt101p-Mms22p ligase associates with replisome complex during S phase via Ctf4p; required for accurate meiotic chromosome segregation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      771940..776304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182209.1 → NP_013424.1  TPA: Mms22p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013424.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYW3, Q06164
      UniProtKB/TrEMBL
      B5VNL6, C8ZDT2, N1P1L4
      Conserved Domains (1) summary
      pfam09462
      Location:758 → 1218
      Mus7; Mus7/MMS22 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06164.1

    Gene LinkOut

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